Health-related quality of life in Chinese children and adolescents with cancer

IF 1.7 4区医学 Q2 NURSING Japan Journal of Nursing Science Pub Date : 2023-10-10 DOI:10.1111/jjns.12564

Lei Cheng, Min Wu, Ling Yu

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Abstract

Aim

Cancer diagnosis and related treatment can have multiple impacts on children's health-related quality of life (HRQoL). This study aimed to determine profiles of HRQoL in Chinese children and adolescents with cancer based on patient-reported outcomes.

Methods

This cross-sectional study recruited 310 pediatric patients with cancer (in treatment and survivorship) aged 8–17 years old and their family caregivers from four hospitals in China. The participants were asked to complete the PROMIS Pediatric-25 Profile 2.0, along with a demographic and clinical characteristics questionnaire, fatigue screening item, and an item assessing the family caregiver's coping style. Latent profile analysis was used to identify profiles.

Results

Two profiles were identified: Profile 1, “low symptom and high function” (n = 147, 47.4%); and Profile 2, “high symptom and low function” (n = 163, 52.5%). Children reporting ≥3 on the five-point Symptom Distress Scale fatigue screening item were more likely to be in Profile 2 (OR = 1.961; 95% CI: 1.098–3.501). Participants were less likely to be in Profile 2 if they were in survivorship (OR = 0.494; 95% CI: 0.271–0.903), or their caregiver's coping style was identified as facing positively (OR = 0.439; 95% CI: 0.274–0.703).

Conclusion

The identified profiles demonstrate the heterogeneity in HRQoL among pediatric patients with cancer, and the importance of supporting caregivers' coping as a means of supporting the child. Knowledge of these profiles can assist clinicians in better identifying and targeting interventions for children with cancer.

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中国癌症儿童青少年健康相关生活质量研究。

目的：癌症的诊断和相关治疗可对儿童健康相关的生活质量（HRQoL）产生多种影响。本研究旨在根据患者报告的结果确定中国癌症儿童和青少年的HRQoL特征。方法：这项横断面研究招募了310名年龄在8-17岁的癌症儿童患者（治疗和生存期）来自中国四家医院的40岁老人及其家庭护理人员。参与者被要求完成PROMIS Pediatrics-25 Profile 2.0，以及人口统计学和临床特征问卷、疲劳筛查项目和评估家庭护理者应对方式的项目。潜在剖面分析用于识别剖面。结果：确定了两个图谱：图谱1，“症状低、功能高”（n = 14747.4%）；以及概况2，“高症状和低功能”（n = 163，52.5%）。在五点症状困扰量表疲劳筛查项目中报告≥3的儿童更有可能属于2型（OR = 1.961；95%可信区间：1.098-3.501）。如果参与者处于生存期，则他们不太可能处于第2种情况（OR = 0.494；95%可信区间：0.271-0.903），或其护理者的应对方式被确定为积极面对（or = 0.439；95%CI:0.274-0.703）。了解这些概况可以帮助临床医生更好地识别和针对癌症儿童的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japan Journal of Nursing Science 医学-护理

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Japan Journal of Nursing Science is the official English language journal of the Japan Academy of Nursing Science. The purpose of the Journal is to provide a mechanism to share knowledge related to improving health care and promoting the development of nursing. The Journal seeks original manuscripts reporting scholarly work on the art and science of nursing. Original articles may be empirical and qualitative studies, review articles, methodological articles, brief reports, case studies and letters to the Editor. Please see Instructions for Authors for detailed authorship qualification requirement.