White and Gray Matter Abnormalities in Young Adult Females with Dependent Personality Disorder: A Diffusion-Tensor Imaging and Voxel-Based Morphometry Study.

IF 2.3 3区 医学 Q3 CLINICAL NEUROLOGY Brain Topography Pub Date : 2024-01-01 Epub Date: 2023-10-13 DOI:10.1007/s10548-023-01013-3
Zhixia Cui, Liangliang Meng, Qing Zhang, Jing Lou, Yuan Lin, Yueji Sun
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Abstract

We applied diffusion-tensor imaging (DTI) including measurements of fractional anisotropy (FA), a parameter of neuronal fiber integrity, mean diffusivity (MD), a parameter of brain tissue integrity, as well as voxel-based morphometry (VBM), a measure of gray and white matter volume, to provide a basis to improve our understanding of the neurobiological basis of dependent personality disorder (DPD). DTI was performed on young girls with DPD (N = 17) and young female healthy controls (N = 17). Tract-based spatial statistics (TBSS) were used to examine microstructural characteristics. Gray matter volume differences between the two groups were investigated using voxel-based morphometry (VBM). The Pearson correlation analysis was utilized to examine the relationship between distinct brain areas of white matter and gray matter and the Dy score on the MMPI. The DPD had significantly higher fractional anisotropy (FA) values than the HC group in the right retrolenticular part of the internal capsule, right external capsule, the corpus callosum, right posterior thalamic radiation (include optic radiation), right cerebral peduncle (p < 0.05), which was strongly positively correlated with the Dy score of MMPI. The volume of gray matter in the right postcentral gyrus and left cuneus in DPD was significantly increased (p < 0.05), which was strongly positively correlated with the Dy score of MMPI (r1,2= 0.467,0.353; p1,2 = 0.005,0.04). Our results provide new insights into the changes in the brain structure in DPD, which suggests that alterations in the brain structure might implicate the pathophysiology of DPD. Possible visual and somatosensory association with motor nerve circuits in DPD.

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依赖性人格障碍年轻成年女性的白质和灰质异常:一项基于张量成像和体素的形态学研究。
我们应用了扩散张量成像(DTI),包括分数各向异性(FA)、神经元纤维完整性参数、平均扩散率(MD)、脑组织完整性参数的测量,以及基于体素的形态计量学(VBM)、灰质和白质体积的测量,为进一步了解依赖性人格障碍(DPD)的神经生物学基础提供依据。对患有DPD的年轻女孩进行DTI(N = 17) 和年轻女性健康对照组(N = 17) 。基于区域的空间统计学(TBSS)被用于检验微观结构特征。使用基于体素的形态计量学(VBM)研究两组之间的灰质体积差异。Pearson相关分析用于检查脑白质和灰质的不同区域与MMPI上的Dy评分之间的关系。DPD在内囊的右透镜状后部分、右外囊、胼胝体、右丘脑后辐射(包括光辐射)、右脑脚的各向异性分数(FA)值显著高于HC组(p 1,2=0.4670.353;p1,2=0.005,0.04)。我们的结果为DPD中大脑结构的变化提供了新的见解,这表明大脑结构的改变可能与DPD的病理生理学有关。DPD患者的视觉和体感可能与运动神经回路有关。
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来源期刊
Brain Topography
Brain Topography 医学-临床神经学
CiteScore
4.70
自引率
7.40%
发文量
41
审稿时长
3 months
期刊介绍: Brain Topography publishes clinical and basic research on cognitive neuroscience and functional neurophysiology using the full range of imaging techniques including EEG, MEG, fMRI, TMS, diffusion imaging, spectroscopy, intracranial recordings, lesion studies, and related methods. Submissions combining multiple techniques are particularly encouraged, as well as reports of new and innovative methodologies.
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