Cone-beam computed tomography-guided online-adaptive radiotherapy for inoperable right colon cancer: First in human

Q1 Nursing Technical Innovations and Patient Support in Radiation Oncology Pub Date : 2023-09-26 DOI:10.1016/j.tipsro.2023.100220

Julien Pierrard , Damien Dumont , David Dechambre , Marc Van den Eynde , Astrid De Cuyper , Geneviève Van Ooteghem

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Abstract

We report the case of a medically inoperable patient with localised colon cancer. Due to symptomatic bleeding, definitive radiotherapy (5 daily fractions of 5 Gy) has been performed using cone-beam computed tomography-based online-adaptive radiotherapy (ART). Online-ART enables compensation of interfraction motion of abdominal organs by performing daily delineation of organs at risk (OARs) and target volumes. Daily treatment replanning maximised target volume coverage while lowering the dose to OARs. Intrafraction variation of the tumour was still significant and had to be incorporated in the planning target volume margin computation. After the treatment, the patient did not develop any acute radiotherapy-induced adverse events and had no further rectal bleeding either at the end of the radiotherapy or at oncological follow-up 4 months later. Online-ART for colon cancer is feasible and is a valuable alternative when surgery is not an option.

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锥束计算机断层扫描引导下的在线自适应放疗治疗不能手术的右结肠癌:首次在人类中应用

我们报告了一例因局部结肠癌癌症而无法手术的患者。由于症状性出血，使用基于锥束计算机断层扫描的在线自适应放射治疗（ART）进行了明确的放射治疗（每天5次，每次5 Gy）。在线ART能够通过每天描绘危险器官（OAR）和目标体积来补偿腹部器官的交叉运动。每日治疗重新规划最大限度地扩大了目标体积覆盖范围，同时将剂量降至OARs。肿瘤的分数内变异仍然显著，必须纳入计划目标体积裕度计算中。治疗后，患者没有出现任何急性放疗引起的不良事件，在放疗结束时或4个月后的肿瘤学随访中也没有进一步的直肠出血。Online-ART治疗结肠癌癌症是可行的，并且在不能选择手术的情况下是一种有价值的替代方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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