In blood we trust: anemia as a negative healing prognostic factor in diabetic foot patients

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Acta Diabetologica Pub Date : 2023-10-17 DOI:10.1007/s00592-023-02188-8

Francesco Giangreco, Elisabetta Iacopi, Vittorio Malquori, Letizia Pieruzzi, Chiara Goretti, Alberto Piaggesi

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Abstract

Aim

Anemia has been associated with severity of diabetic foot (DF) disease. Our study aimed to evaluate whether the presence of anemia could decrease the healing chances in DF.

Methods

We retrospectively analyzed all patients admitted in our department in 2021 for DF, dividing them according to presence (Group A) or absence (Group B) of anemia. Groups were compared for clinical and demographic characteristics, procedures and outcomes: healing rate (HR) at 6 months, healing time (HT) and recurrence rate (RR) at 12 months.

Results

We sorted out data from 196 consecutive patients: 114 (58%) in Group A and 82 (42%) in B. Group A had a higher male prevalence and a longer duration of disease. Group A showed lower hemoglobin concentration (10.3 ± 1.3 g/dL vs 13.1 ± 1.4 g/dL, p < 0.002) and red blood cells count (3.4 ± 0.5 × 10⁶/mL vs 4.8 ± 0.6 × 10⁶/mL, p = 0.004). Group A presented a lower HR (55.2% vs 76.8%, p = 0.0028), no differences in HT and a higher RR (23.6% vs 17.1%, p < 0.02). Cox’s logistic regression on healing confirmed the negative impact of anemia: hazard ratio 2.8 (CI 95% 1.4–5.4, p = 0.0037).

Conclusions

Anemia is frequent in DF and associates to a reduction in healing chances and an increase in recurrences representing an independent predictor of healing failure.

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在血液中，我们相信：贫血是糖尿病足患者的一个负面愈合预后因素。

目的：贫血与糖尿病足（DF）疾病的严重程度有关。我们的研究旨在评估贫血的存在是否会降低DF的治愈机会。方法：我们回顾性分析了2021年我科因DF入院的所有患者，并根据贫血的存在（A组）或不存在（B组）对其进行了划分。比较各组的临床和人口统计学特征、程序和结果：6个月时的愈合率（HR）、12个月的愈合时间（HT）和复发率（RR）。结果：我们整理了196名连续患者的数据：A组114人（58%），B组82人（42%）。A组男性患病率较高，疾病持续时间较长。A组血红蛋白浓度较低（10.3 ± 1.3 g/dL与13.1 ± 1.4 g/dL，p 6/mL vs 4.8 ± 0.6 × 106/mL，p = 0.004）。A组的HR较低（55.2%对76.8%，p = 0.0028），HT无差异，RR较高（23.6%对17.1%，p 结论：贫血在DF中很常见，与愈合机会的减少和复发率的增加有关，这是愈合失败的独立预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.