Epicardial adipose tissue as a prognostic marker in acute pulmonary embolism.

IF 1.1 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Herz Pub Date : 2024-06-01 Epub Date: 2023-10-17 DOI:10.1007/s00059-023-05210-5

Anar Aghayev, Mattes Hinnerichs, Andreas Wienke, Hans-Jonas Meyer, Alexey Surov

{"title":"Epicardial adipose tissue as a prognostic marker in acute pulmonary embolism.","authors":"Anar Aghayev, Mattes Hinnerichs, Andreas Wienke, Hans-Jonas Meyer, Alexey Surov","doi":"10.1007/s00059-023-05210-5","DOIUrl":null,"url":null,"abstract":"Background: Epicardial adipose tissue (EAT) has been established as a quantitative imaging biomarker associated with disease severity in coronary heart disease. Our aim was to use this prognostic marker derived from computed tomography pulmonary angiography (CTPA) for the prediction of mortality and prognosis in patients with acute pulmonary embolism.Methods: The clinical database was retrospectively screened for patients with acute pulmonary embolism between 2015 and 2021. Overall, 513 patients (216 female, 42.1%) were included in the analysis. The study end-point was 30-day mortality. Epicardial adipose tissue was measured on the diagnostic CTPA in a semiquantitative manner. The volume and density of EAT were measured for every patient.Results: Overall, 60 patients (10.4%) died within the 30-day observation period. The mean EAT volume was 128.3 ± 65.0 cm3 in survivors and 154.6 ± 84.5 cm3 in nonsurvivors (p = 0.02). The density of EAT was -79.4 ± 8.3 HU in survivors and -76.0 ± 8.4 HU in nonsurvivors (p = 0.86), and EAT density was associated with 30-day mortality (odds ratio [OR] = 1.07; 95% confidence interval [CI]: 1.03; 1.1, p < 0.001) but did not remain statistically significant in multivariable analysis. No association was identified between EAT volume and 30-day mortality (OR = 1.0; 95% CI: 1.0; 1.0, p = 0.48).Conclusion: There might be an association between EAT density and mortality in patients with acute pulmonary embolism. Further studies are needed to elucidate the prognostic relevance of EAT parameters in patients with acute pulmonary embolism.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"219-223"},"PeriodicalIF":1.1000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11136740/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Herz","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00059-023-05210-5","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/17 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Epicardial adipose tissue (EAT) has been established as a quantitative imaging biomarker associated with disease severity in coronary heart disease. Our aim was to use this prognostic marker derived from computed tomography pulmonary angiography (CTPA) for the prediction of mortality and prognosis in patients with acute pulmonary embolism.

Methods: The clinical database was retrospectively screened for patients with acute pulmonary embolism between 2015 and 2021. Overall, 513 patients (216 female, 42.1%) were included in the analysis. The study end-point was 30-day mortality. Epicardial adipose tissue was measured on the diagnostic CTPA in a semiquantitative manner. The volume and density of EAT were measured for every patient.

Results: Overall, 60 patients (10.4%) died within the 30-day observation period. The mean EAT volume was 128.3 ± 65.0 cm³ in survivors and 154.6 ± 84.5 cm³ in nonsurvivors (p = 0.02). The density of EAT was -79.4 ± 8.3 HU in survivors and -76.0 ± 8.4 HU in nonsurvivors (p = 0.86), and EAT density was associated with 30-day mortality (odds ratio [OR] = 1.07; 95% confidence interval [CI]: 1.03; 1.1, p < 0.001) but did not remain statistically significant in multivariable analysis. No association was identified between EAT volume and 30-day mortality (OR = 1.0; 95% CI: 1.0; 1.0, p = 0.48).

Conclusion: There might be an association between EAT density and mortality in patients with acute pulmonary embolism. Further studies are needed to elucidate the prognostic relevance of EAT parameters in patients with acute pulmonary embolism.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

心外膜脂肪组织作为急性肺栓塞的预后标志物。

背景：心外膜脂肪组织（EAT）已被确定为与冠心病疾病严重程度相关的定量成像生物标志物。我们的目的是使用这种源自计算机断层扫描肺动脉造影（CTPA）的预后标志物来预测急性肺栓塞患者的死亡率和预后。方法：回顾性筛选2015年至2021年间急性肺栓塞患者的临床数据库。总体而言，513名患者（216名女性，42.1%）被纳入分析。研究终点为30天死亡率。在诊断性CTPA上以半定量的方式测量心外膜脂肪组织。测量每位患者EAT的体积和密度。结果：总的来说，60名患者（10.4%）在30天的观察期内死亡。平均EAT体积为128.3 ± 65 幸存者为cm3，154.6 ± 84.5 cm3在非湍流中（p = 0.02）。EAT的密度为-79.4 ± 8.3 幸存者HU和-76.0 ± 8.4 非幸存者的HU（p = 0.86），EAT密度与30天死亡率相关（比值比[OR] = 1.07；95%置信区间[CI]：1.03；1.1，p 结论：EAT密度与急性肺栓塞患者的死亡率可能存在相关性。需要进一步的研究来阐明EAT参数与急性肺栓塞患者预后的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Herz 医学-心血管系统

CiteScore

3.00

自引率

5.90%

发文量

审稿时长

4-8 weeks

期刊介绍： Herz is the high-level journal for further education for all physicians interested in cardiology. The individual issues of the journal each deal with specific topics and comprise review articles in English and German written by competent and esteemed authors. They provide up-to-date and comprehensive information concerning the speciality dealt with in the issue. Due to the fact that all relevant aspects of the pertinent topic of an issue are considered, an overview of the current status and progress in cardiology is presented. Reviews and original articles round off the spectrum of information provided.