Correlation Between Hypercoagulable State and Severity Level of Ischemic Stroke With Covid-19 Infection.

IF 2.1 Q3 HEMATOLOGY Journal of Blood Medicine Pub Date : 2023-10-11 eCollection Date: 2023-01-01 DOI:10.2147/JBM.S429357
Lisda Amalia
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Abstract

Background: Hypercoagulable state in acute ischemic stroke patients with COVID-19, was found to occur in most cases, may affect the severity and clinical outcome of acute ischemic stroke with COVID-19. Ischemic stroke patients with COVID-19 infection have worsen prognosis in mortality regarding hypercoagulable state condition.

Objective: The study aims to determine the relationship between the hypercoagulable state and the severity of acute ischemic stroke patients with COVID-19.

Methods: This study is a retrospective analytic study using a cross-sectional method in acute ischemic stroke who meet the criteria must have focal clinical symptoms or global dysfunction lasting more than 24 hours, be caused by vascular factors, be confirmed positive for COVID-19, NIHSS (admission and discharge), and have an examination of D-dimer and/or fibrinogen. Chi-Square is used for data processing relationship analysis.

Results: A total of 32 patients met the inclusion and exclusion criteria of this study. Elevated D-dimer and/or fibrinogen were found in 28 patients (87.5%), confirming a hypercoagulable state. In this study, the average value of D-dimer was 5.3 mg/mL, and fibrinogen was 479 mg/dL. Based on the admission NIHSS score, it was found that most of the patients had moderate strokes with an average NIHSS score of 12. The chi-square test results showed no relationship between the hypercoagulable state and the severity of acute ischemic stroke as measured by NIHSS admission (p=0.333), but it was closely related to NIHSS exit (p=0.02). The finding supports that 40.62% of acute ischemic stroke patients with COVID-19 confirmed to have a hypercoagulable state had a death discharge status.

Conclusion: There is no significant relationship between hypercoagulable state and stroke severity on admission, but it closely related to NIHSS on discharge and high mortality in acute ischemic stroke patients with COVID-19.

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新冠肺炎感染缺血性卒中高凝状态与严重程度的相关性。
背景:新冠肺炎急性缺血性脑卒中患者的高凝状态在大多数情况下发生,可能影响新冠肺炎急性缺血性脑中风的严重程度和临床结果。新冠肺炎感染的缺血性卒中患者在高凝状态下的死亡率预后恶化。目的:本研究旨在确定COVID-19急性缺血性脑卒中患者的高凝状态与严重程度之间的关系,由血管因素引起,被确认为新冠肺炎阳性,NIHSS(入院和出院),并检查D-二聚体和/或纤维蛋白原。卡方用于数据处理关系分析。结果:共有32名患者符合本研究的纳入和排除标准。28名患者(87.5%)发现D-二聚体和/或纤维蛋白原升高,证实其处于高凝状态。在本研究中,D-二聚体的平均值为5.3 mg/mL,纤维蛋白原为479 mg/dL。根据入院NIHSS评分,发现大多数患者患有中度中风,平均NIHSS评分为12。chi-square检验结果显示,高凝状态与NIHSS入院测量的急性缺血性卒中严重程度之间没有关系(p=0.333),但与NIHSS退出密切相关(p=0.02)。该发现支持40.62%的新冠肺炎确诊为高凝状态的急性缺血性脑卒中患者具有死亡出院状态。结论:新冠肺炎急性缺血性脑卒中患者入院时高凝状态与脑卒中严重程度无显著关系,但与出院时NIHSS及高死亡率密切相关。
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来源期刊
CiteScore
3.50
自引率
0.00%
发文量
94
审稿时长
16 weeks
期刊介绍: The Journal of Blood Medicine is an international, peer-reviewed, open access, online journal publishing laboratory, experimental and clinical aspects of all topics pertaining to blood based medicine including but not limited to: Transfusion Medicine (blood components, stem cell transplantation, apheresis, gene based therapeutics), Blood collection, Donor issues, Transmittable diseases, and Blood banking logistics, Immunohematology, Artificial and alternative blood based therapeutics, Hematology including disorders/pathology related to leukocytes/immunology, red cells, platelets and hemostasis, Biotechnology/nanotechnology of blood related medicine, Legal aspects of blood medicine, Historical perspectives. Original research, short reports, reviews, case reports and commentaries are invited.
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