Ajeet M. Wagle , Smita R. Hegde , Srinivasan Sanjay , Kah-Guan Au Eong
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引用次数: 2
Abstract
Purpose
Dengue fever (DF) epidemics in Singapore in 2005–2006 and 2007 were caused predominantly by dengue virus serotypes 1 (DENV-1) and 2 (DENV-2) respectively. We investigated the prevalence of ophthalmic manifestations during these consecutive epidemics.
Methods
Seropositive DF patients admitted to the hospital during two separate dengue epidemics were enrolled from June 2005 to December 2007. Demographic, ophthalmic, and laboratory data were collected. The primary outcome measures were differences in ophthalmic and laboratory features across the two epidemics. Factors associated with increased risk of developing various DF-related ophthalmic manifestations were the secondary outcome measures.
Results
Of the 115 patients enrolled, 109 (94.7%; 33 in 2005–2006 and 76 in 2007) completed the eye screening protocol. Majority of patients were Chinese (65, 59.6%) and males (81, 74.3%). The mean age was 40.8 years (range, 18–87). Colour vision impairment (12 vs 14 [36.4% vs 18.7%]; P = 0.04), cotton wool spots (10 vs 3 [30.3% vs 3.9%]; P < 0.001), bleeding diathesis (7 vs 3 [21.2% vs 3.9%]; P = 0.004) and abnormal liver function (mean alanine amino-transferase [150.2 U/L vs 68.28 U/L; P = 0.001], mean aspartate amino-transferase [196.86 U/L vs 99.53 U/L; P = 0.002], total protein [68.43 g/L vs 72.27 g/L; P = 0.016], serum albumin [36.86 g/L vs 40.5 g/L; P = 0.001]) were noted more often in DF epidemics predominantly caused by DENV-1 compared to DENV-2.
Conclusions
A higher prevalence of colour vision impairment, cotton wool spots, bleeding diathesis, and abnormal liver function was found in DF epidemics predominantly caused by DENV-1 compared to DENV-2.
目的2005-2006年和2007年新加坡登革热流行主要分别由登革热病毒血清型1 (DENV-1)和2 (DENV-2)引起。我们调查了这些连续流行期间眼部表现的患病率。方法收集2005年6月至2007年12月两次登革热流行期间住院的DF血清阳性患者。收集了人口统计学、眼科和实验室数据。主要结局指标是两种流行的眼科和实验室特征的差异。与各种df相关的眼部表现风险增加相关的因素是次要结果测量。结果入组的115例患者中,109例(94.7%;33名(2005-2006年)和76名(2007年)完成了眼部筛查方案。以华人(65例,59.6%)和男性(81例,74.3%)居多。平均年龄40.8岁(18 ~ 87岁)。色觉障碍(12 vs 14 [36.4% vs 18.7%];P = 0.04),棉毛斑(10 vs 3 [30.3% vs 3.9%];P & lt;0.001),出血素质(7 vs 3 [21.2% vs 3.9%];P = 0.004)和肝功能异常(平均丙氨酸氨基转移酶[150.2 U/L vs 68.28 U/L;P = 0.001],平均天冬氨酸氨基转移酶[196.86 U/L vs 99.53 U/L;P = 0.002),血清总蛋白(68.43 g / L和72.27 g / L;P = 0.016),血清白蛋白(36.86 g / L和40.5 g / L;P = 0.001])在主要由DENV-1引起的登革热流行中比由DENV-2引起的登革热流行更常见。结论以DENV-1为主的DF流行中色觉障碍、棉斑、出血、肝功能异常的发生率高于DENV-2。