Protein-modified nanomaterials: emerging trends in skin wound healing

IF 4.703 3区材料科学 Nanoscale Research Letters Pub Date : 2023-10-16 DOI:10.1186/s11671-023-03903-8

Deepinder Sharda, Pawandeep Kaur, Diptiman Choudhury

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Abstract

Prolonged inflammation can impede wound healing, which is regulated by several proteins and cytokines, including IL-4, IL-10, IL-13, and TGF-β. Concentration-dependent effects of these molecules at the target site have been investigated by researchers to develop them as wound-healing agents by regulating signaling strength. Nanotechnology has provided a promising approach to achieve tissue-targeted delivery and increased effective concentration by developing protein-functionalized nanoparticles with growth factors (EGF, IGF, FGF, PDGF, TGF-β, TNF-α, and VEGF), antidiabetic wound-healing agents (insulin), and extracellular proteins (keratin, heparin, and silk fibroin). These molecules play critical roles in promoting cell proliferation, migration, ECM production, angiogenesis, and inflammation regulation. Therefore, protein-functionalized nanoparticles have emerged as a potential strategy for improving wound healing in delayed or impaired healing cases. This review summarizes the preparation and applications of these nanoparticles for normal or diabetic wound healing and highlights their potential to enhance wound healing.

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蛋白质修饰纳米材料：皮肤伤口愈合的新趋势。

长期炎症会阻碍伤口愈合，伤口愈合受到多种蛋白质和细胞因子的调节，包括IL-4、IL-10、IL-13和TGF-β。研究人员已经研究了这些分子在靶位点的浓度依赖性作用，通过调节信号强度将其开发为伤口愈合剂。纳米技术通过开发具有生长因子（EGF、IGF、FGF、PDGF、TGF-β、TNF-α和VEGF）、抗糖尿病伤口愈合剂（胰岛素）和细胞外蛋白（角蛋白、肝素和丝素蛋白）的蛋白质功能化纳米颗粒，为实现组织靶向递送和提高有效浓度提供了一种很有前途的方法。这些分子在促进细胞增殖、迁移、ECM产生、血管生成和炎症调节中发挥着关键作用。因此，蛋白质功能化纳米颗粒已成为改善延迟或受损愈合情况下伤口愈合的潜在策略。本文综述了这些纳米颗粒在正常或糖尿病伤口愈合中的制备和应用，并强调了它们增强伤口愈合的潜力。

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来源期刊

Nanoscale Research Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

15.00

自引率

0.00%

发文量

110

审稿时长

2.5 months

期刊介绍： Nanoscale Research Letters (NRL) provides an interdisciplinary forum for communication of scientific and technological advances in the creation and use of objects at the nanometer scale. NRL is the first nanotechnology journal from a major publisher to be published with Open Access.