Protective effect of nitroglycerin ointment and dimethyl sulfoxide on necrosis of skin flaps in rats.

Cirugia y cirujanos Pub Date : 2023-01-01 DOI:10.24875/CIRU.22000203

Miguel L De la Parra-Marquez, Abril Peralta-Enriquez, Victor G Peña, Sergio Charles-Lozoya

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Abstract

Objective: To compare the protective effect of nitroglycerin ointment 2% and Dimethylsulfoxide (DMSO) in dorsal flaps of the rat.

Methods: A blind, experimental study was conducted in 24 male Wistar rats, with a mean weight of 320 (286-376) grams. Group 1: Control. Petrolatum jelly (Vaseline), n = 8, Group 2: Nitroglycerin (NTG) ointment 2% (Nitro-Bid, Altana Co.) n = 8, and Group 3: DMSO gel 90% (Neogen corp. Lexington KY, 40611), n = 8.

Results: A total of 24 rats were operated on in the 6-month period of this study. Using a non-parametric Mann-Whitney U-test analysis, a statistically significant p was obtained between the control group and 2% NTG ointment, both in the area of necrosis and in the healthy area (p = 0.026). In contrast, the comparison between DMSO [CH3) 2SO] and the control group (p = 0.180) and between both study groups, with a p = 0.18, was not significant.

Conclusions: Our study concluded that there is a protective effect of 2% NTG ointment for flap survival in relation to the control group (petrolatum). DMSO administered topically did not show a protective effect, compared to the control group.

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硝酸甘油软膏和二甲基亚砜对大鼠皮瓣坏死的保护作用。

目的：比较2%硝酸甘油软膏和二甲基亚砜对大鼠背侧皮瓣的保护作用。方法：对24只平均体重320（286-376）克的雄性Wistar大鼠进行盲法实验研究。第1组：对照组。凡士林（凡士林），n=8，第2组：2%硝酸甘油（NTG）软膏（Nitro-Bid，Altana Co.）n=8，和第3组：90%二甲基亚砜凝胶（Neogen corp.Lexington KY，40611），n=8.结果：在本研究的6个月内，共有24只大鼠接受了手术。使用非参数Mann-Whitney U型检验分析，对照组和2%NTG软膏在坏死区域和健康区域均获得统计学显著性p（p=0.026）。相比之下，DMSO[CH3）2SO]和对照组之间（p=0.0180）以及两个研究组之间（p=0.18）的比较不显著。结论：我们的研究得出结论，与对照组（矿脂）相比，2%NTG软膏对皮瓣存活具有保护作用。与对照组相比，局部施用DMSO没有显示出保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cirugia y cirujanos

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