IL-6, IL-10 and TNF-α gene polymorphisms in preeclampsia: a case-control study in a Mexican population.

IF 1 Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2023-10-16 DOI:10.5603/gpl.94272

Carlos Ernesto Mora Palazuelos, Elsa Maribel Aguilar Medina, Mariana Melisa Avendaño Felix, Rosalio Ramos Payán, Mercedes Bermudez Cortez, Leticia Lara Avila, Adrian Herrera Salazar, Joel Murillo Llanes, Guzmán Sanchez-Schmitz, Jose Geovanni Romero Quintana

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Abstract

Objectives: We focused our study on examining the genotype and allele frequency of IL-6 (rs1800795), TNF-α (rs1800629) and IL-10 (rs1800872) single nucleotide polymorphisms (SNP) on preeclampsia (PE) diagnosed Mexican pregnant women.

Material and methods: A case-control study was designed including 86 preeclampsia patients and 100 normotensives pregnancies from Women's Hospital of Culiacan, Mexico. Genotyping of IL-6, TNF-α and IL-10 was performed using TaqMan SNP Genotyping.

Results: Not significant association was found between development of PE and genotypic (p > 0.05) and allelic (p > 0.05) frequencies of IL-6, TNF-α and IL-10 SNPs. Genotype distributions of IL-6 (p = 0.599), TNF-α (p = 0.721) and IL-10 (p = 0.761) polymorphisms in the two groups were in agreement with Hardy-Weinberg equilibrium.

Conclusions: According to the findings, the IL-6, TNF-α and IL-10 SNPs are not exponents of susceptibility to developing PE.

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子痫前期患者IL-6、IL-10和TNF-α基因多态性的病例对照研究。

目的：我们的研究重点是检测被诊断为先兆子痫（PE）的墨西哥孕妇IL-6（rs1800795）、TNF-α（rs1800629）和IL-10（rs1800872）单核苷酸多态性（SNP）的基因型和等位基因频率。材料和方法：设计了一项病例对照研究，包括来自墨西哥库利亚坎妇女医院的86名先兆子痫患者和100名血压正常的孕妇。结果：PE的发生与IL-6、TNF-α和IL-10 SNPs的基因型（p>0.05）和等位基因频率（p>0.05）无显著相关性。IL-6（p=0.599）、TNF-α（p=0.721）和IL-10（p=0.761）多态性在两组中的基因型分布符合Hardy-Weinberg平衡。结论：根据研究结果，IL-6、TNF-α和IL-10 SNPs不是PE易感性的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ginekologia polska

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