Segmental Erythema Multiforme: An Unusual Drug Reaction to Anastrozole.

Sanja Poduje, Luka Vujević, Nika Filipović, Majda Vučić, Marija Buljan
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Abstract

Erythema multiforme (EM) is an immune-mediated, mucocutaneous hypersensitivity syndrome that can occur as a result of various medications, including a wide range of antineoplastic and hormonal drugs. Anastrozole, a nonselective aromatase inhibitor used in breast cancer management has been associated with different cutaneous side effects, of which EM is rarely seen and usually in a minor or major form with typical target lesions. This is a short report of a patient who developed a rare cutaneous side effect after the use of aromatase inhibitor anastrozole - segmental erythema multiforme in cancer-affected area. Cutaneous adverse effects limited to cancer-affected breast are extremely rare but should be considered in everyday dermatological practice. We find this case instructive not only because of the rarity of the segmental EM, but also because, contrary to classical teaching, drug eruption due to anastrozole occurred months, not days after the initiation of therapy.

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节段性多发性红斑:一种对阿曲唑的异常药物反应。
多形性红斑(EM)是一种免疫介导的粘膜皮肤超敏综合征,可由各种药物引起,包括各种抗肿瘤和激素药物。Anastrozole是一种用于癌症治疗的非选择性芳香化酶抑制剂,与不同的皮肤副作用有关,其中EM很少出现,通常以轻微或主要形式出现,具有典型的靶病变。这是一个简短的报告,患者在使用芳香化酶抑制剂阿那曲唑后出现罕见的皮肤副作用-癌症影响区域的节段性多形性红斑。仅限于癌症影响的乳房的皮肤不良反应极为罕见,但应在日常皮肤科实践中考虑。我们发现这个病例很有启发性,不仅因为节段EM的罕见,而且因为与经典教学相反,阿曲唑引起的药疹发生在治疗开始后的几个月,而不是几天。
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