Nocardiopyrone C, a New Antimicrobial Pyran-2-one Derivative from a Marine-derived Actinomycete Strain Nocardiopsis aegyptia ZSN1

Abstract

: A new pyran-2-one derivative, Nocardiopyrone C ( 1 ), and three known compounds, Nocardiopyrone B ( 2 ), 1-hydroxy-4-methoxy-2-naphthoic acid ( 3 ), and 2-(aminocarbonyl)-phenylcarbamate ( 4 ) were identified from the marine-derived Nocardiopsis aegyptia ZSN1. The chemical structure of the novel compound ( 1 ) was ascertained as (7 R )-5-(methoxymethyl)-3-methyl-6-(pentan-2-yl)-2 H -pyran-2-one using HRESIMS data, spectroscopic data, and ECD calculations. All four isolated compounds displayed antimicrobial activity, with the new compound 1 having the same MIC value of 50.0 µ M against E. coli , S. aureus , and C. albicans .