Identity crisis of nanostructures inside the human body: a perspective on inflammation

IF 4.1 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Frontiers in Nanotechnology Pub Date : 2023-08-22 DOI:10.3389/fnano.2023.1256952
Sarmistha Saha, L. Saso
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Abstract

Advances in nanotechnology have attracted a lot of potential medical applications, such as therapeutic agents, diagnostics, and theranostics for complex diseases. The intersection of nanotechnologies, molecular and cell biology, and medicine can function to improve human health and quality of life, making healthcare a primary target of nanotechnology research. However, this seems like a promising future, ethical, health, and safety concerns must be considered before a reasoned evaluation of the situation can be made. Most nanostructures, however, typically fail to reach their intended targets because they get trapped inside innate immune cells. Since little is known about how nanomaterials and nanotechnologies change their identity inside the biological system, there is a wide-ranging discussion on possible concerns. In this regard, we present a perspective on how biological systems may interact with nanoscale materials and how that interaction might affect cellular recognition of nanostructures. We will also discuss dynamic modifications of the nanomaterials inside biological systems and, in particular, inflammation responses.
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人体内纳米结构的身份危机:对炎症的看法
纳米技术的进步吸引了许多潜在的医学应用,如治疗剂、诊断学和复杂疾病的治疗学。纳米技术、分子和细胞生物学以及医学的交叉可以改善人类健康和生活质量,使医疗保健成为纳米技术研究的主要目标。然而,这似乎是一个很有希望的未来,在对情况做出合理的评估之前,必须考虑伦理、健康和安全问题。然而,大多数纳米结构通常无法到达预定的目标,因为它们被困在先天免疫细胞中。由于人们对纳米材料和纳米技术如何在生物系统中改变它们的特性知之甚少,因此就可能存在的问题进行了广泛的讨论。在这方面,我们提出了一个关于生物系统如何与纳米材料相互作用以及这种相互作用如何影响纳米结构的细胞识别的观点。我们还将讨论生物系统内纳米材料的动态修饰,特别是炎症反应。
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来源期刊
Frontiers in Nanotechnology
Frontiers in Nanotechnology Engineering-Electrical and Electronic Engineering
CiteScore
7.10
自引率
0.00%
发文量
96
审稿时长
13 weeks
期刊最新文献
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