A systematic review and meta-analysis of effect of synthetic erythropoietin on hemoglobin in dialysis patients

IF 0.2 Q4 UROLOGY & NEPHROLOGY Journal of Renal Injury Prevention Pub Date : 2021-05-18 DOI:10.34172/jrip.2021.28

H. Nourmohammadi, Zahra Abdan, Melina Ramezanpour, Razieh Abdollahipour, Diana Sarokhani, M. Fakhri, A. Hasanpour Dehkordi

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Abstract

Introduction: Anemia is a common complication of chronic kidney disease (CKD) due to the insufficient production of erythropoietin by the kidneys. The administration of erythropoietin is one of the most common methods for the treatment of patients with anemia. Objectives: This study aimed to investigate the effect of the administration of synthetic erythropoietin on hemoglobin levels in dialysis patients using a systematic review and meta-analysis. Methods: In order to identify the related studies, the international databases of Web of Science, PubMed, Scopus, and Embase were searched from 2015 to 2020 using standard and valid keywords. The data were analyzed using STATA software (version 14), and a p-value of less than 0.05 was considered statistically significant. Results: In 12 reviewed articles with a sample size of 4,060 individuals, the standard effect size of the effect of synthetic erythropoietin on Hb in dialysis patients was reported as 2.08 (95% CI: 1.53-2.63), which was statistically significant; however, erythropoietin biosimilars did not show similar results. Conclusion: The administration of erythropoietin to hemodialysis patients increases Hb levels by more than 2 units.

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合成红细胞生成素对透析患者血红蛋白影响的系统评价和荟萃分析

简介：贫血是慢性肾脏疾病（CKD）的常见并发症，原因是肾脏产生的红细胞生成素不足。红细胞生成素的给药是治疗贫血患者最常见的方法之一。目的：本研究旨在通过系统综述和荟萃分析研究合成红细胞生成素对透析患者血红蛋白水平的影响。方法：为了确定相关研究，使用标准有效的关键词检索2015年至2020年的国际数据库Web of Science、PubMed、Scopus和Embase。使用STATA软件（版本14）对数据进行分析，p值小于0.05被认为具有统计学意义。结果：在12篇样本量为4060人的综述文章中，合成红细胞生成素对透析患者Hb影响的标准效应大小为2.08（95%CI:1.53-2.63），具有统计学意义；然而，红细胞生成素生物类似物并没有显示出类似的结果。结论：血液透析患者应用促红细胞生成素可使Hb水平升高2个单位以上。

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来源期刊

Journal of Renal Injury Prevention UROLOGY & NEPHROLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： The Journal of Renal Injury Prevention (JRIP) is a quarterly peer-reviewed international journal devoted to the promotion of early diagnosis and prevention of renal diseases. It publishes in March, June, September and December of each year. It has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views and renal biopsy teaching point. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of renal failure and modalities in the treatment of diabetic nephropathy. A further aim of this journal is to emphasize and strengthen the link between renal pathologists/nephropathologists and nephrologists. In addition, JRIP welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical nephrology. Futuristic conceptual hypothesis that integrate various fields of acute kidney injury and renal tubular cell protection are encouraged to be submitted.