What Counts as the Environment in Epigenetics? Knowledge and Ignorance in the Entrepreneurial University

IF 2.5 3区 哲学 Q1 CULTURAL STUDIES Science As Culture Pub Date : 2022-03-02 DOI:10.1080/09505431.2022.2043840
C. Pinel
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引用次数: 4

Abstract

ABSTRACT Epigenetics research is well-known for its attention to the ‘environment,’ as it explores how what surrounds the genes impacts gene regulation. In addition, epigenetics has commonly been described as the new socio-biology capable of capturing how the broadly defined social environment, structured by social inequalities, shapes biology. Yet, this vision is not realised in the context of the entrepreneurial university. In the two laboratories where ethnographic fieldwork was conducted, scientists focus their research on narrow articulations of the notion of environment, around individual ‘lifestyle’ or micro-environments within which tumours develop. While the entrepreneurial university is characterised by multiple authoritative agencies evaluating and legitimising research, the narrowing of research priorities in epigenetics can be explained by the overlap of multiple scales of environment in which such authoritative agencies exercise authority: a disciplinary environment with peer-reviewed journals, an institutional environment with research managers, a market environment with funding bodies and commercial firms. In a general context of precarity, these environmental scales successively shape the content of research, by imposing filters on researchers’ practices, while implementing incentives encouraging certain forms of research. In particular, it favours a certain type of epigenetics research that is individualised and clinically centred, while leaving unexplored the social determinants of health and its biological corollary. This article adds to existing scholarship by, first, operationalising the broad concept of entrepreneurial university through the analysis of authoritative agencies and their role on research practices, and second, by providing empirical evidence of the interplay between research content and research environment.
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什么算是表观遗传学中的环境?创业型大学的知识与无知
摘要表观遗传学研究以其对“环境”的关注而闻名,因为它探索了基因周围的环境如何影响基因调控。此外,表观遗传学通常被描述为一种新的社会生物学,能够捕捉由社会不平等构成的广义社会环境如何塑造生物学。然而,这一愿景并没有在创业大学的背景下实现。在进行民族志实地调查的两个实验室中,科学家们将研究重点放在对环境概念的狭隘理解上,围绕个体的“生活方式”或肿瘤发展的微观环境。虽然创业大学的特点是由多个权威机构评估研究并使其合法化,但表观遗传学研究重点的缩小可以解释为这些权威机构行使权力的多个环境尺度的重叠:拥有同行评审期刊的学科环境,一个有研究经理的制度环境,一个有资助机构和商业公司的市场环境。在不稳定的普遍背景下,这些环境尺度通过对研究人员的实践进行过滤,同时实施鼓励某些形式研究的激励措施,依次塑造了研究的内容。特别是,它倾向于某种类型的表观遗传学研究,这种研究是个性化的和以临床为中心的,同时没有探索健康的社会决定因素及其生物学必然结果。本文补充了现有的学术成果,首先,通过分析权威机构及其在研究实践中的作用,运用创业大学的广泛概念,其次,通过提供研究内容和研究环境之间相互作用的经验证据。
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来源期刊
Science As Culture
Science As Culture Multiple-
CiteScore
5.20
自引率
3.80%
发文量
28
期刊介绍: Our culture is a scientific one, defining what is natural and what is rational. Its values can be seen in what are sought out as facts and made as artefacts, what are designed as processes and products, and what are forged as weapons and filmed as wonders. In our daily experience, power is exercised through expertise, e.g. in science, technology and medicine. Science as Culture explores how all these shape the values which contend for influence over the wider society. Science mediates our cultural experience. It increasingly defines what it is to be a person, through genetics, medicine and information technology. Its values get embodied and naturalized in concepts, techniques, research priorities, gadgets and advertising. Many films, artworks and novels express popular concerns about these developments. In a society where icons of progress are drawn from science, technology and medicine, they are either celebrated or demonised. Often their progress is feared as ’unnatural’, while their critics are labelled ’irrational’. Public concerns are rebuffed by ostensibly value-neutral experts and positivist polemics. Yet the culture of science is open to study like any other culture. Cultural studies analyses the role of expertise throughout society. Many journals address the history, philosophy and social studies of science, its popularisation, and the public understanding of society.
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