Volumetric Assessment of Hippocampus and Subcortical Gray Matter Regions in Alzheimer Disease and Amnestic Mild Cognitive Impairment

IF 1.3 4区 医学 Q4 BEHAVIORAL SCIENCES Cognitive and Behavioral Neurology Pub Date : 2022-06-01 DOI:10.1097/WNN.0000000000000296
Tuğberk Andaç Topkan, Nesrin Erdoğan, Berrak Barutcu, E. Cindil, E. T. Tali, Y. Karaman
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Abstract

Background: Quantitative MRI assessment methods have limited utility due to a lack of standardized methods and measures for Alzheimer disease (AD) and amnestic mild cognitive impairment (aMCI). Objective: To employ a relatively new and easy-to-use quantitative assessment method to reveal volumetric changes in subcortical gray matter (GM) regions, hippocampus, and global intracranial structures as well as the diagnostic performance and best thresholds of total hippocampal volumetry in individuals with AD and those with aMCI. Method: A total of 74 individuals—37 with mild to moderate AD, 19 with aMCI, and 18 with normal cognition (NC)—underwent a 3T MRI. Fully automated segmentation and volumetric measurements were performed. Results: The AD and aMCI groups had smaller volumes of amygdala, nucleus accumbens, and hippocampus compared with the NC group. These same two groups had significantly smaller total white matter volume than the NC group. The AD group had smaller total GM volume compared with the aMCI and NC groups. The thalamus in the AD group showed a subtle atrophy. There were no significant volumetric differences in the caudate nucleus, putamen, or globus pallidus between the groups. Conclusion: The amygdala and nucleus accumbens showed atrophy comparable to the hippocampal atrophy in both the AD and aMCI groups, which may contribute to cognitive impairment. Hippocampal volumetry is a reliable tool for differentiating between AD and NC groups but has substantially less power in differentiating between AD and aMCI groups. The loss of total GM volume differentiates AD from aMCI and NC.
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阿尔茨海默病和轻度认知障碍患者海马和皮质下灰质区域的容量评估
背景:定量MRI评估方法的实用性有限,因为对阿尔茨海默病(AD)和遗忘性轻度认知障碍(aMCI)缺乏标准化的方法和措施。目的:采用一种相对较新的、易于使用的定量评估方法,揭示AD和aMCI患者皮质下灰质(GM)区、海马和整体颅内结构的体积变化,以及海马总体积测量的诊断性能和最佳阈值。方法:74例患者(轻度至中度AD 37例,aMCI 19例,认知正常18例)接受3T MRI检查。进行全自动分割和体积测量。结果:与NC组相比,AD组和aMCI组的杏仁核、伏隔核和海马体积较小。这两组的总白质体积明显小于NC组。与aMCI和NC组相比,AD组的GM总体积较小。阿尔茨海默病组的丘脑出现了轻微的萎缩。两组之间尾状核、壳核或苍白球的体积没有显著差异。结论:AD和aMCI组杏仁核和伏隔核萎缩与海马萎缩相当,可能导致认知功能障碍。海马体积测量是区分AD和NC组的可靠工具,但在区分AD和aMCI组方面的作用要小得多。总GM体积的损失是AD与aMCI和NC的区别。
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来源期刊
CiteScore
2.40
自引率
7.10%
发文量
68
审稿时长
>12 weeks
期刊介绍: Cognitive and Behavioral Neurology (CBN) is a forum for advances in the neurologic understanding and possible treatment of human disorders that affect thinking, learning, memory, communication, and behavior. As an incubator for innovations in these fields, CBN helps transform theory into practice. The journal serves clinical research, patient care, education, and professional advancement. The journal welcomes contributions from neurology, cognitive neuroscience, neuropsychology, neuropsychiatry, and other relevant fields. The editors particularly encourage review articles (including reviews of clinical practice), experimental and observational case reports, instructional articles for interested students and professionals in other fields, and innovative articles that do not fit neatly into any category. Also welcome are therapeutic trials and other experimental and observational studies, brief reports, first-person accounts of neurologic experiences, position papers, hypotheses, opinion papers, commentaries, historical perspectives, and book reviews.
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