{"title":"Structure and Photosensitaizer Ability of Polymethine Dyes in Photodynamic Therapy: A Review","authors":"A. A. Ishchenko, A. T. Syniugina","doi":"10.1007/s11237-023-09754-9","DOIUrl":null,"url":null,"abstract":"<div><div><p>Different approaches to the development of promising photosensitizers based on polymethine dyes (PD) for photodynamic therapy are systematized, summarized, and analyzed. PD of the near-IR spectral range has drawn special attention. The influence of a heavy atom (chalcogens, halogens, and noble metals), the chromophore interaction, electron transfer, and free radicals on the singlet oxygen generation by PD is discussed. The PD photodynamic activity mechanisms under hypoxia conditions are considered. The PD structural modifications that ensure their targeted delivery to cancer cells are analyzed.</p></div></div>","PeriodicalId":796,"journal":{"name":"Theoretical and Experimental Chemistry","volume":"58 6","pages":"373 - 401"},"PeriodicalIF":0.7000,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Theoretical and Experimental Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11237-023-09754-9","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 7
Abstract
Different approaches to the development of promising photosensitizers based on polymethine dyes (PD) for photodynamic therapy are systematized, summarized, and analyzed. PD of the near-IR spectral range has drawn special attention. The influence of a heavy atom (chalcogens, halogens, and noble metals), the chromophore interaction, electron transfer, and free radicals on the singlet oxygen generation by PD is discussed. The PD photodynamic activity mechanisms under hypoxia conditions are considered. The PD structural modifications that ensure their targeted delivery to cancer cells are analyzed.
期刊介绍：
Theoretical and Experimental Chemistry is a journal for the rapid publication of research communications and reviews on modern problems of physical chemistry such as:
a) physicochemical bases, principles, and methods for creation of novel processes, compounds, and materials;
b) physicochemical principles of chemical process control, influence of external physical forces on chemical reactions;
c) physical nanochemistry, nanostructures and nanomaterials, functional nanomaterials, size-dependent properties of materials.
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