Factor V Leiden mutation detection before AstraZeneca vaccine

Abstract

BacKgrouNd: on the beginning of 2020 the world woke up with a novel coronavirus disease (coVId-19) pandemic caused by sarscoV-2, started in Wuhan, china. several types of vaccine appeared, one of them was astraZeneca (astraZenca, cambridge, uK) vaccine. METHOD(S): This is a single-center retrospective study which included 9 patients who developed DVT after the first dose of AstraZeneca vaccine. they were screened for thrombophilia, including factor V leiden mutation. rEsults: they were found positive for factor V leiden mutation and were treated by Noacs. also, they were advised to delay second dose for 3 months and to shift to another vaccine like sinopharm (china National Pharmaceutical group, Beijing, china). coNclusIoNs: alert should be raised for patients with factor V leiden mutation having a second dose;and for the treatment of the thrombosis condition. Copyright © 2022 EdIZIoNI MINErVa MEdIca.