Surgical Treatment of Patients with Adenocarcinoma of the Distal Esophageal Portion and Gastroesophageal Junction Performed After Neoadjuvant Chemotherapy and Combined Chemoradiation
G. Yankov, M. Alexieva, M. Kovacheva-Slavova, B. Vladimirov, E. Mekov
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引用次数: 0
Abstract
Abstract Esophageal carcinoma is an extremely aggressive cancer with an early distant spread, high rate of local recurrence, and low overall survival. Herewith we present 3 patients with advanced moderately and low differentiated adenocarcinomas, who underwent neoadjuvant chemotherapy (nCT) (two patients) and combined nCT with neoadjuvant radiation therapy (nRT) (one patient), followed by radical surgery. Subtotal esophageal resection, proximal gastric resection, and intrathoracic right gastroesophagoplasty a modo Ivor-Lewis were performed in the first two patients, while total gastrectomy, distal third esophageal resection, splenectomy and left intrathoracic esophagojejunoplasty a modo Roux were performed in the third one. A literature review of the role of neoadjuvant chemoradiotherapy (nCRT) as part of a trimodality therapy for advanced esophageal carcinoma is presented.
食管癌是一种侵袭性极强的肿瘤，早期远处扩散，局部复发率高，总生存率低。我们报告了3例晚期中、低分化腺癌患者，接受了新辅助化疗(nCT)(2例)和新辅助放疗(nRT)(1例)，并行根治性手术。前2例患者行食管次全切除术、胃近端切除术、胸内右胃食管成形术a modo Ivor-Lewis;第三例患者行全胃切除术、远端第三食管切除术、脾切除术、左胸内食管空肠成形术a modo Roux。文献综述了新辅助放化疗(nCRT)作为晚期食管癌三段式治疗的一部分的作用。
期刊介绍：
About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.
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