{"title":"Comparison of SUV<sub>A</sub><sub>/V</sub> and SUV<sub>A</sub><sub>-V</sub> for Evaluating Atherosclerotic Inflammation in <sup>18</sup>F-FDG PET/CT.","authors":"Jeongryul Ryu, Shin Ae Han, Sangwon Han, Sunju Choi, Dae Hyuk Moon, Minyoung Oh","doi":"10.1007/s13139-023-00822-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the clinical significance of two parameters, division of standardized uptake value (SUV) of target arterial activity by background venous blood pool activity (SUV<sub>A/V</sub>) and subtraction of background venous blood pool activity from SUV of target arterial activity (SUV<sub>A-V</sub>) of carotid arteries with atherosclerotic plaques using <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT).</p><p><strong>Methods: </strong>Patients aged 50 years or more who were diagnosed with carotid artery stenosis of 50% or more with carotid Doppler ultrasonography and had torso <sup>18</sup>F-FDG PET/CT were enrolled retrospectively and classified patients who developed cerebrovascular events (CVEs) within 5 years after <sup>18</sup>F-FDG PET/CT scan as the active group and patients who did not experience the CVE within 5 years as an inactive group. We calculated SUV<sub>A/V</sub> and SUV<sub>A-V</sub> using measurements of SUV<sub>max</sub> of carotid arteries and mean SUV of superior vena cava (SVC).</p><p><strong>Results: </strong>SUV<sub>A-V</sub>, SUV<sub>A-V_high</sub>, and SUV<sub>A-V_low</sub> were significantly higher in the active group than in the inactive group, but neither SUV<sub>A/V</sub>, SUV<sub>A/V_high</sub>, nor SUV<sub>A/V_low</sub> showed significant differences between the active and inactive groups. The difference in rank between groups of SUV<sub>A/V_high</sub> and SUV<sub>A/V_low</sub> was greater than the difference in rank between groups of SUV<sub>A-V_high</sub> and SUV<sub>A-V_low</sub>. The CVE incidence differed between SUV<sub>A/V_high</sub> and SUV<sub>A/V_low</sub> of high carotid FDG uptake, but the CVE incidence did not differ between SUV<sub>A-V_high</sub> and SUV<sub>A-V_low</sub> of high carotid FDG uptake.</p><p><strong>Conclusion: </strong>SUV<sub>A-V</sub> may be a more rational solution than SUV<sub>A/V</sub> for evaluating atherosclerotic plaque inflammation on <sup>18</sup>F-FDG PET/CT.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"25-31"},"PeriodicalIF":17.7000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10796899/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s13139-023-00822-5","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/5 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
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Abstract
Purpose: This study aimed to compare the clinical significance of two parameters, division of standardized uptake value (SUV) of target arterial activity by background venous blood pool activity (SUVA/V) and subtraction of background venous blood pool activity from SUV of target arterial activity (SUVA-V) of carotid arteries with atherosclerotic plaques using 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT).
Methods: Patients aged 50 years or more who were diagnosed with carotid artery stenosis of 50% or more with carotid Doppler ultrasonography and had torso 18F-FDG PET/CT were enrolled retrospectively and classified patients who developed cerebrovascular events (CVEs) within 5 years after 18F-FDG PET/CT scan as the active group and patients who did not experience the CVE within 5 years as an inactive group. We calculated SUVA/V and SUVA-V using measurements of SUVmax of carotid arteries and mean SUV of superior vena cava (SVC).
Results: SUVA-V, SUVA-V_high, and SUVA-V_low were significantly higher in the active group than in the inactive group, but neither SUVA/V, SUVA/V_high, nor SUVA/V_low showed significant differences between the active and inactive groups. The difference in rank between groups of SUVA/V_high and SUVA/V_low was greater than the difference in rank between groups of SUVA-V_high and SUVA-V_low. The CVE incidence differed between SUVA/V_high and SUVA/V_low of high carotid FDG uptake, but the CVE incidence did not differ between SUVA-V_high and SUVA-V_low of high carotid FDG uptake.
Conclusion: SUVA-V may be a more rational solution than SUVA/V for evaluating atherosclerotic plaque inflammation on 18F-FDG PET/CT.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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