Occupational exposure in lead and zinc mines induces oxidative stress in miners lymphocytes: Role of mitochondrial/lysosomal damage

IF 1.8 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR Main Group Metal Chemistry Pub Date : 2020-01-01 DOI:10.1515/mgmc-2020-0019

Enayatollah Seydi, Mahshid Soltani, M. Ramazani, M. Zarei, J. Pourahmad

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引用次数: 3

Abstract

Abstract The purpose of this research was to determine mitochondrial and lysosomal damage and oxidative stress status in blood lymphocytes of lead-zinc miners. This research was performed in 10 mine workers who have been in contact with lead and zinc in comparison to a control group containing 10 healthy volunteers. Lymphocytes were isolated from peripheral blood using the Ficoll standard method and then mitochondrial and lysosomal damage and oxidative stress were evaluated. The level of reactive oxygen species (ROS), collapse in the mitochondrial membrane potential (MMP) collapse, and glutathione disulfide (GSSG) content, and lysosomal damage in miners were higher than the control group. Also, viability and glutathione (GSH) content were decreased. The lymphocytes of workers of a lead-zinc mine are more susceptible to oxidative stress, mitochondrial and lysosomal damage. The proper use of safety equipment can reduce the risk of toxic agents and their subsequent hazards for mine workers.

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铅和锌矿山的职业暴露诱导矿工淋巴细胞的氧化应激：线粒体/溶酶体损伤的作用

摘要本研究旨在测定铅锌矿矿工血淋巴细胞线粒体和溶酶体的损伤及氧化应激状态。这项研究是在10名接触过铅和锌的矿工中进行的，与包含10名健康志愿者的对照组相比。使用Ficoll标准方法从外周血中分离淋巴细胞，然后评估线粒体和溶酶体损伤以及氧化应激。矿工的活性氧（ROS）水平、线粒体膜电位崩溃（MMP）、谷胱甘肽二硫化物（GSSG）含量以及溶酶体损伤均高于对照组。此外，活力和谷胱甘肽（GSH）含量降低。铅锌矿工人的淋巴细胞更容易受到氧化应激、线粒体和溶酶体损伤。正确使用安全设备可以降低有毒物质的风险及其对矿山工人的后续危害。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Main Group Metal Chemistry CHEMISTRY, INORGANIC & NUCLEAR-CHEMISTRY, ORGANIC

CiteScore

4.10

自引率

27.80%

发文量

审稿时长

4 weeks

期刊介绍： This journal is committed to the publication of short communications, original research, and review articles within the field of main group metal and semi-metal chemistry, Main Group Metal Chemistry is an open-access, peer-reviewed journal that publishes in ongoing way. Papers addressing the theoretical, spectroscopic, mechanistic and synthetic aspects of inorganic, coordination and organometallic main group metal and semi-metal compounds, including zinc, cadmium and mercury are welcome. The journal also publishes studies relating to environmental aspects of these metals, their toxicology, release pathways and fate. Articles on the applications of main group metal chemistry, including in the fields of polymer chemistry, agriculture, electronics and catalysis, are also accepted.