Structural characteristics and biological activity of different alginate blocks extracted from brown seaweed Turbinaria ornata

IF 1.2 4区化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Carbohydrate Chemistry Pub Date : 2021-01-01 DOI:10.1080/07328303.2021.1928155

Thuy T.T. Thanh , Thu T.M. Quach , Van T.T. Tran , Thanh V. Nguyen , Shiho Suzuki , Shinichi Kitamura , Yoshiaki Yuguchi

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引用次数: 2

Abstract

An alginate (molecular weight [Mw] = 64.8 × 10³, F_M = 0.505) was extracted from brown seaweed Turbinaria ornata, and were separated into three fractions, G-blocks (Mw = 8.0 × 10³, F_M = 0.141), M-blocks (Mw = 4.0 × 10³, F_M = 0.952), and MG-blocks (Mw = 8.0 × 10³, F_M = 0.279). According to biological evaluations in terms of antimicrobial, antioxidant, and cytotoxic activities, the native alginate was not a high bioactive compound, but its two main fractions, G-blocks and M-blocks especially M-blocks, showed higher activities. The native alginate and two main fractions were found to have a linear single-chain conformation in saline solution as observed by small-angle X-ray scattering (SAXS) measurements.

Graphical Abstract

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褐藻中不同藻酸块的结构特征及生物活性研究

摘要从褐藻Turbinaria ornata中提取了一种分子量为64.8 × 103, F M = 0.505的海藻酸盐，并将其分为3个组分:g -区块(Mw = 8.0 × 103, F M = 0.141)、M-区块(Mw = 4.0 × 103, F M = 0.952)和mg -区块(Mw = 8.0 × 103, F M = 0.279)。从抗菌、抗氧化和细胞毒活性的生物学评价来看，天然海藻酸盐不是一种高活性化合物，但其两个主要组分g块和m块，特别是m块具有较高的活性。通过小角x射线散射(SAXS)测量，发现天然海藻酸盐和两个主要组分在盐水溶液中具有线性单链构象。图形抽象

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来源期刊

Journal of Carbohydrate Chemistry 化学-生化与分子生物学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Carbohydrate Chemistry serves as an international forum for research advances involving the chemistry and biology of carbohydrates. The following aspects are considered to fall within the scope of this journal: -novel synthetic methods involving carbohydrates, oligosaccharides, and glycoconjugates- the use of chemical methods to address aspects of glycobiology- spectroscopic and crystallographic structure studies of carbohydrates- computational and molecular modeling studies- physicochemical studies involving carbohydrates and the chemistry and biochemistry of carbohydrate polymers.