Viral Suppression and Its Associated Factors in HIV Patients on Highly Active Antiretroviral Therapy (HAART): A Retrospective Study in the Ho Municipality, Ghana

IF 1.1 Q4 INFECTIOUS DISEASES AIDS Research and Treatment Pub Date : 2020-02-13 DOI:10.1155/2020/9247451
S. Lokpo, Patrick Jnr Ofori-Attah, L. Ameke, C. Obirikorang, V. Orish, G. E. Kpene, E. Agboli, Gideon Kye-Duodu, J. Deku, Benedict Awadzi, Mark Noagbe, Seyram Tetteh Quarshie
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引用次数: 26

Abstract

Background. The WHO targets to end HIV/AIDS as a public health problem by 2030. The introduction of the ambitious “90-90-90” strategy to attain this target is expected to be achieved by the year 2020. However, there is lack of regional data, especially on the third “90.” This study sought to assess the rate and associated factors of viral suppression among people living with HIV (PLWH) on highly active antiretroviral therapy (HAART) at the Antiretroviral Therapy (ART) Clinic in a Ghanaian health facility. Method. The study design was a retrospective analysis of secondary data of 284 HIV registrants on HAART for at least 6 months at the ART Clinic from July 2016 to April 2019. Data on sociodemography including age, gender, marital status, education, and occupation as well as pharmacological (type of medication and duration on medication) and laboratory variable (current viral load results) were extracted from patients’ folders. Viral suppression and failure were determined using the WHO definitions (viral suppression as viral load ). However, regular clinic attendance (used as proxy for medication adherence) ( ) and being on HAART for more than three (3) years ( ) were associated with viral suppression. Conclusion. The rate of viral suppression among PLWH on HAART in the Ho municipality fell short of the WHO target. However, the study identified regular ART clinic attendance and treatment >3 years as factors associated with viral suppression.
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在接受高效抗逆转录病毒治疗(HAART)的HIV患者中病毒抑制及其相关因素:一项来自加纳Ho市的回顾性研究
背景世界卫生组织的目标是到2030年结束艾滋病毒/艾滋病这一公共卫生问题。为实现这一目标而实施的雄心勃勃的“90-90-90”战略预计将在2020年实现。然而,缺乏区域数据,尤其是关于第三个“90”的数据。这项研究试图评估加纳卫生机构抗逆转录病毒治疗诊所接受高活性抗逆转录病毒疗法(HAART)的艾滋病毒感染者(PLWH)的病毒抑制率和相关因素。方法该研究设计对2016年7月至2019年4月在抗逆转录病毒治疗诊所接受HAART治疗至少6个月的284名HIV登记者的二次数据进行了回顾性分析。从患者文件夹中提取社会人口学数据,包括年龄、性别、婚姻状况、教育和职业,以及药理学(药物类型和用药时间)和实验室变量(当前病毒载量结果)。使用世界卫生组织定义确定病毒抑制和失败(病毒抑制为病毒载量)。然而,定期就诊(用作药物依从性的指标)()和接受HAART治疗三(3)年以上()与病毒抑制有关。结论Ho市PLWH对HAART的病毒抑制率低于世界卫生组织的目标。然而,该研究确定,定期参加抗逆转录病毒疗法诊所就诊和治疗>3年是与病毒抑制相关的因素。
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来源期刊
AIDS Research and Treatment
AIDS Research and Treatment INFECTIOUS DISEASES-
CiteScore
3.10
自引率
0.00%
发文量
13
审稿时长
18 weeks
期刊介绍: AIDS Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focused on all aspects of HIV and AIDS, from the molecular basis of disease to translational and clinical research. In addition, articles relating to prevention, education, and behavior change will be considered
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