Effect of electroacupuncture at low frequencies on the Yintang (extra) and Baihui (GV20) points in a murine model with induced depression

Abstract

Objective

To evaluate the effect of electroacupuncture at low frequencies in a murine model using a modified depression model with the forced swimming test for seven weeks.

Material and methods

12 mice of the CD-1 strain, two groups (n = 6), a group with electroacupuncture (EA) treatment (4–6 Hz, 14 sessions of 20 min, for seven weeks) and a group of sham acupuncture (Sham), using a modified depression model, with the forced swim test.

Results and conclusions

In this study, in the EA group a significant effect on depression was shown using the forced swim test. It was determined that the group with EA increased their body weight (on average by 4 g), which could be interpreted as a behavior that seeks to preserve life and therefore mice retain their appetite toward achieving adequate growth and development. In this way, it can be shown that EA has an antidepressant effect, favoring increased motivation to survive and reducing behaviors corresponding to states of depression.