Clinicopathological Characteristics and Survival of Triple-Negative Breast Cancer Patients: A single Institution Study from Egypt

W. Makar
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Abstract

Background: Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is characterized by being more aggressive, presentation in younger age, and higher response rate to chemotherapy. It is more likely to recur and to metastasize early. Methods: Retrospective review of the medical records of TNBC patients treated in a single Egyptian cancer center during a 4-year period. Results: Sixty-five patients were included. Forty-six percent of patients were < 50 years old and 22% had a positive family history. Ten (15%) patients were metastatic at presentation. Modified radical mastectomy was performed in 42% of patients and adjuvant chemotherapy was administered in 55% of them. Relapse occurred in 12 (22%) out of 55 patients who had no distant metastasis at presentation (M0). The overall survival rate of M0 patients at 12, 24 and 36 months was 96%, 91% and 88%; respectively. The disease-free survival rate of M0 patients at 12, 24 and 36 months was 90%, 81% and 71%; respectively. Conclusion: In Egyptian female patients,TNBC is an aggressive subtype of breast cancer that occurs at younger age. Frequently, it is of high grade and presents in an advanced stage.
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癌症三阴性患者的临床病理特征和生存率:埃及的一项单一机构研究
背景:三阴性乳腺癌(TNBC)是乳腺癌的一种亚型,其特点是更具侵袭性,出现在较年轻的年龄,对化疗的反应率较高。它更容易复发和早期转移。方法:回顾性分析4年间在埃及某癌症中心接受治疗的TNBC患者的医疗记录。结果:纳入65例患者。46%的患者年龄小于50岁,22%的患者有阳性家族史。10例(15%)患者出现转移。42%的患者行改良根治性乳房切除术,55%的患者行辅助化疗。55例患者在就诊时无远处转移(M0),其中12例(22%)复发。M0患者12、24、36个月总生存率分别为96%、91%、88%;分别。M0患者12、24、36个月无病生存率分别为90%、81%、71%;分别。结论:在埃及女性患者中,TNBC是一种侵袭性亚型乳腺癌,发生在较年轻的年龄。通常,它是高品位的,呈现在高级阶段。
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审稿时长
8 weeks
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