Protecting Group-Free Gold-Catalyzed Synthesis of 2-Acylidene-3-Oxindoles and Azaaurones via a Double Oxidation Strategy

IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Israel Journal of Chemistry Pub Date : 2023-08-10 DOI:10.1002/ijch.202300094
Xinlong Song, Ximei Zhao, Zhongyi Zeng, Frank Rominger, Matthias Rudolph, A. Stephen K. Hashmi
{"title":"Protecting Group-Free Gold-Catalyzed Synthesis of 2-Acylidene-3-Oxindoles and Azaaurones via a Double Oxidation Strategy","authors":"Xinlong Song,&nbsp;Ximei Zhao,&nbsp;Zhongyi Zeng,&nbsp;Frank Rominger,&nbsp;Matthias Rudolph,&nbsp;A. Stephen K. Hashmi","doi":"10.1002/ijch.202300094","DOIUrl":null,"url":null,"abstract":"<p>A one-pot synthesis of 2-acylidene-3-oxindole and azaaurone derivatives starting from <i>O</i>-alkynylanilines and alkynes is presented. By means of oxidative gold catalysis the two starting materials are transferred to reactive intermediates that <i>in situ</i> form the target products. This double oxidation strategy enables a protecting group-free step-economic strategy towards these valuable substrate classes.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"63 9","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300094","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Israel Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ijch.202300094","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

A one-pot synthesis of 2-acylidene-3-oxindole and azaaurone derivatives starting from O-alkynylanilines and alkynes is presented. By means of oxidative gold catalysis the two starting materials are transferred to reactive intermediates that in situ form the target products. This double oxidation strategy enables a protecting group-free step-economic strategy towards these valuable substrate classes.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
通过双氧化策略保护无基金催化合成2 -酰基- 3 -氧吲哚和氮唑酮
介绍了以O -炔基苯胺和炔为起始原料,一锅法合成2 -酰基- 3 -氧吲哚和氮唑酮衍生物的方法。通过氧化金催化,将两种起始材料转移到原位形成目标产物的反应中间体。这种双重氧化策略使得对这些有价值的基材类别的保护组-无步骤-经济策略成为可能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Israel Journal of Chemistry
Israel Journal of Chemistry 化学-化学综合
CiteScore
6.20
自引率
0.00%
发文量
62
审稿时长
6-12 weeks
期刊介绍: The fledgling State of Israel began to publish its scientific activity in 1951 under the general heading of Bulletin of the Research Council of Israel, which quickly split into sections to accommodate various fields in the growing academic community. In 1963, the Bulletin ceased publication and independent journals were born, with Section A becoming the new Israel Journal of Chemistry. The Israel Journal of Chemistry is the official journal of the Israel Chemical Society. Effective from Volume 50 (2010) it is published by Wiley-VCH. The Israel Journal of Chemistry is an international and peer-reviewed publication forum for Special Issues on timely research topics in all fields of chemistry: from biochemistry through organic and inorganic chemistry to polymer, physical and theoretical chemistry, including all interdisciplinary topics. Each topical issue is edited by one or several Guest Editors and primarily contains invited Review articles. Communications and Full Papers may be published occasionally, if they fit with the quality standards of the journal. The publication language is English and the journal is published twelve times a year.
期刊最新文献
Cover Picture: (Isr. J. Chem. 8-9/2024) Special Issue on RNA-Based Catalysts that Revolutionized the Discovery of Bioactive Peptides Hexagonal and Trigonal Quasiperiodic Tilings Breaking the Degeneracy of Sense Codons – How Far Can We Go? Cover Picture: (Isr. J. Chem. 6-7/2024)
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1