Emerging technologies for cardiac tissue engineering and artificial hearts.

Smart medicine Pub Date : 2023-02-16 eCollection Date: 2023-02-01 DOI:10.1002/SMMD.20220040
Lingyu Sun, Yu Wang, Dongyu Xu, Yuanjin Zhao
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Abstract

Heart diseases, especially cardiovascular diseases, have brought heavy burden on society for their high morbidity and mortality. In clinical, heart transplantation is recognized as an effective strategy to rescue the lives of patients, while it may suffer from lack of donors and possible immune responses. In view of this, tremendous efforts have been devoted to developing alternative strategies to recover the function and promote the regeneration of cardiac tissues. As an emerging field blending cell biology and material science, tissue engineering technique allows the construction of biomimetic living complexes as organ substitutes for heart repair. In this review, we will present the recent progress in cardiac tissue engineering and artificial hearts. After introducing the critical elements in cardiac tissue engineering, we will present advanced fabrication methods to achieve scaffolds with desired micro/nanostructure design as well as the applications of these bioinspired scaffolds. We will also discuss the current dilemma and possible development direction from a biomedical perspective.

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心脏组织工程和人工心脏的新兴技术
心脏病特别是心血管疾病的高发病率和高死亡率给社会带来了沉重的负担。在临床中,心脏移植被认为是挽救患者生命的有效策略,但它可能存在供体不足和可能的免疫反应。鉴于此,人们一直致力于研究恢复心脏组织功能和促进心脏组织再生的替代策略。组织工程技术是细胞生物学和材料科学相结合的新兴领域,它允许构建仿生生命复合物作为心脏修复的器官替代品。本文就心脏组织工程和人工心脏的研究进展作一综述。在介绍心脏组织工程的关键要素后,我们将介绍先进的制造方法,以实现所需的微/纳米结构设计以及这些生物启发支架的应用。我们还将从生物医学的角度讨论当前的困境和可能的发展方向。
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