Organoids-on-a-chip

Yaqing Wang, Tingting Tao, J. Qin
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Abstract

Organoids-on-a-chip is a newly emerging and frontier field with a marriage of organoids and microfluidic organ-on-a-chip technology. The synergistic engineering strategies can be adopted to build organ model systems in high fidelity, and to hold great potential in studies of organ development, disease modeling, drug discovery and regenerative medicine. In this review, we introduce the origin, key features and recent progress of organoids-on-chips. The future opportunities and major challenges to advance organoids-on-a-chip systems are also discussed.
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Organoids-on-a-chip
类器官芯片技术是类器官与微流控芯片技术相结合的新兴前沿领域。采用协同工程策略可以构建高保真度的器官模型系统,在器官发育、疾病建模、药物发现和再生医学研究中具有很大的潜力。本文综述了芯片类器官的起源、主要特点和最新进展。本文还讨论了未来发展类器官芯片系统的机遇和主要挑战。
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