Short-Term Impact of Hematopoietic Stem Cell Transplantation on Depressive Behavior, Cognition and Quality of Life in Leukemia Patients.

IF 0.7 4区医学 Q4 HEMATOLOGY Indian Journal of Hematology and Blood Transfusion Pub Date : 2024-01-01 Epub Date: 2023-04-04 DOI:10.1007/s12288-023-01653-2

Rhythm Joshi, Aakriti Garg, Zehva Khan, Dinesh Bhurani, Nidhi, Mohd Ashif Khan

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Abstract

Hematopoietic stem cell transplantation (HSCT) or Bone Marrow Transplantation (BMT) has significantly improved the survival rates of patients suffering from hematological malignancies. However, the cure can only be achieved at the price of morbidity and long-term complications. Thus, this study aimed to evaluate the short-term effect of HSCT on depressive behavior, cognition, and quality of life (QoL) in leukemia patients. Sixty patients were included in this prospective observational study. The current study assessed depression using Patient Health Questionnaire (PHQ-9) scale, cognition using Montreal Cognitive Assessment (MOCA) scale and QoL using European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ C30) before 7 days of the therapy i.e., preconditioning/baseline (TP1) and after 30 days of the treatment (TP2) in leukemia patients undergoing HSCT. At TP2, there was a significant improvement in PHQ-9 (p = 0.001), MOCA (p < 0.0001), functional scale (p < 0.0001) and global health & QoL scale (p = 0.001) of EORTC QLQ C30 scores whereas there was a significant decrease in symptom scale of EORTC QLQ C30 score (p = 0.005). Furthermore, at TP2 a statistically significant (p < 0.05) negative correlation was observed between MOCA and symptom scale of EORTC QLQ C30 after Pearson correlation analysis. In conclusion, post-30 days of HSCT there was alleviation in depressive behavior, cognition, and QoL in leukemia patients compared to before therapy.

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造血干细胞移植对白血病患者抑郁行为、认知和生活质量的短期影响

造血干细胞移植（HSCT）或骨髓移植（BMT）大大提高了血液恶性肿瘤患者的存活率。然而，治愈是以发病率和长期并发症为代价的。因此，本研究旨在评估造血干细胞移植对白血病患者抑郁行为、认知和生活质量（QoL）的短期影响。这项前瞻性观察研究共纳入了 60 名患者。本研究使用患者健康问卷（PHQ-9）量表评估了接受造血干细胞移植的白血病患者的抑郁情况，使用蒙特利尔认知评估（MOCA）量表评估了认知情况，并使用欧洲癌症研究和治疗组织生活质量问卷（EORTC QLQ C30）评估了治疗前 7 天，即预处理/基线（TP1）和治疗后 30 天（TP2）的生活质量。在 TP2 阶段，EORTC QLQ C30 评分中的 PHQ-9（p = 0.001）和 MOCA（p = 0.001）均有显著改善，而 EORTC QLQ C30 评分中的症状量表则有显著下降（p = 0.005）。此外，在 TP2 阶段，EORTC QLQ C30 评分明显下降（p = 0.005）：

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来源期刊

Indian Journal of Hematology and Blood Transfusion HEMATOLOGY-

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Indian Journal of Hematology and Blood Transfusion is a medium for propagating and exchanging ideas within the medical community. It publishes peer-reviewed articles on a variety of aspects of clinical hematology, laboratory hematology and hemato-oncology. The journal exists to encourage scientific investigation in the study of blood in health and in disease; to promote and foster the exchange and diffusion of knowledge relating to blood and blood-forming tissues; and to provide a forum for discussion of hematological subjects on a national scale. The Journal is the official publication of The Indian Society of Hematology & Blood Transfusion.