Determination of dihydrocapsaicin adulteration in dietary supplements using LC-MS/MS

IF 1.8 Q3 CHEMISTRY, ANALYTICAL Journal of Chemical Metrology Pub Date : 2020-06-10 DOI:10.25135/jcm.36.20.01.1532
Demet Di̇nçel, Hatice Olgan, Zeynep Canbaloğlu, S. Yalçin, A. Erkuçuk, Gizem Tırıs, A. Gören
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引用次数: 5

Abstract

Adulteration of dietary supplements are serious threats to public health in all around of world. Nowadays, in order to obtain the intended effect from natural remedies, the adulteration of natural products via artificial or harmful chemicals are increasing. A rapid LC-MS/MS method for determination of capsaicin and dihydrocapsaicin in dietary supplements via Fortis C18 (150 x 3 mm; 3 μm) column at 25 °C was developed and validated in a mixture of mobile phase A (1 % formic acid solution and 0.1 % ammonium formate in water) and B (1 % formic acid solution and 0.1 % ammonium formate in methanol) with gradient program at a flow rate of 0.35 mL/min. The recoveries of developed methods weytre obtained in the range of % 95.4-106.3 for capsaicin and % 96.3-108.9 for dihydrocapsaicin. This study shows that synthetic compound dihydrocapsaicin is widely use in dietary supplements products for adulteration to increase the effects of product without any declaration.
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hplc -MS/MS法测定膳食补充剂中掺假的二氢辣椒素
膳食补充剂掺假严重威胁着世界各地的公众健康。如今,为了从自然疗法中获得预期的效果,通过人工或有害化学物质掺假的天然产品正在增加。hplc -MS/MS快速测定膳食补充剂中辣椒素和二氢辣椒素的方法在流动相a(1%甲酸溶液和0.1%甲酸铵水溶液)和B(1%甲酸溶液和0.1%甲酸铵甲醇)的混合物中,以梯度程序,流速为0.35 mL/min,在25°C下建立了3 μm)的色谱柱并进行了验证。所建立的方法对辣椒素的回收率为95.4 ~ 106.3,对二氢辣椒素的回收率为96.3 ~ 108.9。本研究表明,合成复合二氢辣椒素被广泛应用于膳食补充剂产品中,在没有任何声明的情况下进行掺假,以增加产品的效果。
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来源期刊
Journal of Chemical Metrology
Journal of Chemical Metrology CHEMISTRY, ANALYTICAL-
CiteScore
2.30
自引率
15.40%
发文量
7
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