CRY1 polymorphism may influence the association of low carbohydrate diet (LCD) score on glucose homeostasis in overweight and obese women

IF 0.4 Q4 ENDOCRINOLOGY & METABOLISM British Journal of Diabetes Pub Date : 2023-03-30 DOI:10.15277/bjd.2023.402
A. Mirzababaei, Farideh Shiraseb, Sara Hajishizari, Mena Farazi, Hadith Tangestani, Leila Khorraminezhad, C. Clark, K. Mirzaei
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Abstract

Background and aims: We sought to examine the interaction between CRY1 genotypes and low carbohydrate diet (LCD) score and the effect on insulin resistance, insulin sensitivity, homeostasis model assessment of insulin resistance (HOMA- IR) and quantitative insulin sensitivity check index (ISQUKI). Methods: This cross-sectional study was conducted with a total of 228 overweight and obese women. The data related to anthropometric and biochemical measures were collected and a food frequency questionnaire (FFQ), with 147 items, was used to assess dietary intake. Based on the FFQ, we calculated an LCD score for each study participant, ranging from 0 to 70. Biochemical assessments, including TC, HDL, LDL, TG, FBS, insulin and HOMA-IR, were performed. Deoxyribonucleic acid (DNA) samples were assessed to be genotyped for the rs2287161, which was genotyped by the restriction fragment length polymorphism (PCR-RFLP) method. A generalised linear model was performed for interaction analysis. Results: The results of the study demonstrated that, after controlling for several confounders, increased adherence to an LCD (T3 vs. T1) in the interaction with one risk allele genotype (CG) increases ISQUKI level (β: 0.001, CI: 0.00, 0.002, p=0.041). Also, there was a marginally negative interaction between higher adherence to LCD and two risk alleles genotype (CC) on insulin level (β: -0.012, CI: 0-0.024, 0.001, p=0.054). Conclusions: This study revealed a negative interaction of CRY1 genotypes with two risk allele and higher LCD adherence on insulin level, and a positive interaction on ISQUKI. However, the mechanism of interaction between LCDs and CRY1 genotypes remains unclear.
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CRY1多态性可能影响超重和肥胖女性低碳水化合物饮食(LCD)评分与葡萄糖稳态的关联
背景与目的:研究CRY1基因型与低碳水化合物饮食(LCD)评分之间的相互作用,以及对胰岛素抵抗、胰岛素敏感性、胰岛素抵抗稳态模型评估(HOMA- IR)和胰岛素敏感性定量检查指数(ISQUKI)的影响。方法:对228名超重和肥胖妇女进行横断面研究。收集了与人体测量和生化测量相关的数据,并使用包含147个项目的食物频率问卷(FFQ)来评估膳食摄入量。基于FFQ,我们计算了每个研究参与者的LCD得分,范围从0到70。进行生化评估,包括TC、HDL、LDL、TG、FBS、胰岛素和HOMA-IR。采用限制性内切片段长度多态性(PCR-RFLP)方法对rs2287161进行基因分型。采用广义线性模型进行相互作用分析。结果:研究结果表明,在控制了几个混杂因素后,与一个风险等位基因基因型(CG)相互作用中增加对LCD的依从性(T3 vs. T1)会增加ISQUKI水平(β: 0.001, CI: 0.00, 0.002, p=0.041)。此外,高依从性LCD与两个风险等位基因基因型(CC)对胰岛素水平有轻微负交互作用(β: -0.012, CI: 0-0.024, 0.001, p=0.054)。结论:CRY1基因型与两个风险等位基因存在负交互作用,与胰岛素水平有较高的LCD依从性,与ISQUKI呈正交互作用。然而,lcd与CRY1基因型之间相互作用的机制尚不清楚。
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来源期刊
British Journal of Diabetes
British Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
自引率
16.70%
发文量
15
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