Elham Nazari , Reza ArefNezhad , Mahla Tabadkani , Amir Hossein Farzin , Mahmood Tara , Seyed Mahdi Hassanian , Majid Khazaei , Gordon A. Ferns , Hamed Tabesh , Amir Avan
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引用次数: 2
Abstract
Background
Despite extensive effort, breast cancer (BC) is still among the most lethal cancer in women. Here we explored the interaction of traditional markers (including pathological, clinical and demographical parameters) associated with breast cancer and 5 genetic variants (e.g., connexin37-rs1764391; ABCB1-rs2032582; CYP1B1-rs1056836; CDKN2A/B-rsrs10811661; CDKN2A/B-rs1333049) in BC.
Methods
Forty variables from 115 patients and 230 healthy individuals (e.g., pathology [T, N, M], genes, biochemical parameters [e.g., CA153, ki_67, ER, CEA] were collected and then analyzed. For studying internal relationships of each variables and as a risk factor, the correlation matrix was used. For implementation, Python programming language 3.7.2 was utilized and the coefficient of correlation between 0.7 and 1 was considered.
Results
Our finding revealed that there is a correlation between Ki_67 and cancer_family, between PR and ER, as well as a correlation between T and P53, CA153, ER, PR and cancer_family. Moreover, our result showed a relationship between Stage with p53, PR, CA153, T and N. Similarly, there was also a correlation between the genetic variables ABCB1 and CYP1B1, CDKN2 and CYP1B1, CDKN2 and ABCB1, CYP1B1 and Connexin37, ABCB1 and Connexin37, CDKN2A and CYP1B1, CDKN2A and ABCB1. The strong correlation of variables was seen stage T N in BC. However,the good correlation of variables was seen rs1764391, Dominnt108, p53, CA153, ER and PR in BC.
Conclusion
Our data provide a novel inside on the potential values of emerging markers in combination with current traditional markers as an approach in identification of high risk breast cancer patients.
Meta GeneBiochemistry, Genetics and Molecular Biology-Genetics
CiteScore
1.10
自引率
0.00%
发文量
20
期刊介绍:
Meta Gene publishes meta-analysis, polymorphism and population study papers that are relevant to both human and non-human species. Examples include but are not limited to: (Relevant to human specimens): 1Meta-Analysis Papers - statistical reviews of the published literature of human genetic variation (typically linked to medical conditionals and/or congenital diseases) 2Genome Wide Association Studies (GWAS) - examination of large patient cohorts to identify common genetic factors that influence health and disease 3Human Genetics Papers - original studies describing new data on genetic variation in smaller patient populations 4Genetic Case Reports - short communications describing novel and in formative genetic mutations or chromosomal aberrations (e.g., probands) in very small demographic groups (e.g., family or unique ethnic group). (Relevant to non-human specimens): 1Small Genome Papers - Analysis of genetic variation in organelle genomes (e.g., mitochondrial DNA) 2Microbiota Papers - Analysis of microbiological variation through analysis of DNA sequencing in different biological environments 3Ecological Diversity Papers - Geographical distribution of genetic diversity of zoological or botanical species.