Antioxidant Actions of Thymoquinone, Silymarin, and Curcumin on Experimental Aortic Ischemia-Reperfusion Model in Wistar Albino Rats

IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Revista Brasileira De Cirurgia Cardiovascular Pub Date : 2022-06-03 DOI:10.21470/1678-9741-2021-0462
M. Yardimci, Mustafa Göz, M. S. Aydın, N. Kankılıç, Ebru Temiz
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Abstract

Introduction Medical improvements are needed to prevent ischemia-reperfusion injury in thoracoabdominal aortic surgery. The aim of this study was to determine the antioxidant effects of thymoquinone, silymarin, and curcumin against ischemia-reperfusion injury associated with abdominal aorta. Methods Twenty-five Wistar albino rats were included in the study. Sham, control, and treatment (thymoquinone, silymarin, and curcumin) groups were set in equal numbers. Ischemia-reperfusion was applied by clamping (120 minutes) and de-clamping (60 minutes) the infrarenal aorta of all groups, except the sham group. Before reperfusion, thymoquinone, silymarin, and curcumin were given intraperitoneally to the treatment groups. After reperfusion, blood samples were taken from the right ventricle. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were studied in serum samples and histopathological examination was performed on the gastrocnemius muscle. Results There was a significant difference in TOS and OSI values between the control and sham groups. Both values were found higher in the control group than in the sham group (P<0.05). OSI values were found to be lower in the thymoquinone group compared to the control group (P<0.05). All three parameters were found to be lower in the silymarin group than in the control group (P<0.05). TAS and TOS levels were found to be higher in the curcumin group than in the control group (P<0.05). There was no histopathological difference between the groups. Conclusion Silymarin and thymoquinone administration decreases oxidative stress in experimental aortic ischemia-reperfusion injury. Antioxidant effect of curcumin was lower than silymarin and thymoquinone.
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百里醌、水飞蓟素和姜黄素对实验性Wistar白化大鼠主动脉缺血再灌注模型的抗氧化作用
引言为了预防胸腹主动脉手术中的缺血再灌注损伤,需要进行医学改良。本研究的目的是确定胸腺醌、水飞蓟素和姜黄素对腹主动脉缺血再灌注损伤的抗氧化作用。方法选择25只Wistar大鼠作为研究对象。Sham、对照组和治疗组(胸腺醌、水飞蓟素和姜黄素)的数量相等。除假手术组外,所有组均通过夹闭(120分钟)和去夹闭(60分钟)肾下主动脉进行缺血再灌注。再灌注前,给药组腹腔注射胸腺醌、水飞蓟素和姜黄素。再灌注后,从右心室采集血样。研究血清样品中的总抗氧化状态(TAS)、总氧化剂状态(TOS)和氧化应激指数(OSI),并对腓肠肌进行组织病理学检查。结果对照组和假手术组TOS和OSI值有显著差异。对照组两个数值均高于假手术组(P<0.05)。胸腺醌组OSI数值低于对照组(P>0.05)。水飞蓟素组三个参数均低于对照组,姜黄素组TAS和TOS水平高于对照组(P<0.05)两组间无组织病理学差异。结论水飞蓟素和胸腺肽醌联合应用可降低实验性主动脉缺血再灌注损伤的氧化应激。姜黄素的抗氧化作用低于水飞蓟素和胸腺醌。
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来源期刊
Revista Brasileira De Cirurgia Cardiovascular
Revista Brasileira De Cirurgia Cardiovascular CARDIAC & CARDIOVASCULAR SYSTEMS-SURGERY
CiteScore
2.10
自引率
0.00%
发文量
176
审稿时长
20 weeks
期刊介绍: Brazilian Journal of Cardiovascular Surgery (BJCVS) is the official journal of the Brazilian Society of Cardiovascular Surgery (SBCCV). BJCVS is a bimonthly, peer-reviewed scientific journal, with regular circulation since 1986. BJCVS aims to record the scientific and innovation production in cardiovascular surgery and promote study, improvement and professional updating in the specialty. It has significant impact on cardiovascular surgery practice and related areas.
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