{"title":"Autoimmune-mediated hemotoxicities","authors":"Alessandra Vultaggio , Andrea Matucci , Francesca Nencini , Susanna Bormioli , Enrico Maggi","doi":"10.1016/j.cotox.2019.12.001","DOIUrl":null,"url":null,"abstract":"<div><p><span>The introduction of biotherapeutics opened a new era of treatment for several inflammatory and cancer diseases, although they are not deprived in toxicity, which can lead to drug interruption. Besides infusion reactions, the occurrence of cytopenia<span><span><span> is a major concern regarding treatment with biologicals. Biotherapeutic-related hemotoxicities is a challenging clinical problem, especially because the definition of the culprit pathological mechanism can be very complicated. In fact, some </span>confounders, such as the baseline disease or concomitant therapies, as well as the direct effect on </span>hematopoiesis of biologicals, all contribute to the growing difficulty in understanding the mechanism of hematotoxicity. This review summarizes the knowledge about the immune-mediated mechanisms of anemia, </span></span>leucopenia<span>, and thrombocytopenia associated with the use of biologicals.</span></p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"19 ","pages":"Pages 63-67"},"PeriodicalIF":3.6000,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.12.001","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202019300269","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
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Abstract
The introduction of biotherapeutics opened a new era of treatment for several inflammatory and cancer diseases, although they are not deprived in toxicity, which can lead to drug interruption. Besides infusion reactions, the occurrence of cytopenia is a major concern regarding treatment with biologicals. Biotherapeutic-related hemotoxicities is a challenging clinical problem, especially because the definition of the culprit pathological mechanism can be very complicated. In fact, some confounders, such as the baseline disease or concomitant therapies, as well as the direct effect on hematopoiesis of biologicals, all contribute to the growing difficulty in understanding the mechanism of hematotoxicity. This review summarizes the knowledge about the immune-mediated mechanisms of anemia, leucopenia, and thrombocytopenia associated with the use of biologicals.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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