{"title":"Targeting Breast Cancer Stem Cells (BCSCs) with Liposomal Formulations","authors":"Sumayah Al-Mahmood","doi":"10.2174/2212697X06666190318150757","DOIUrl":null,"url":null,"abstract":"\n\nBreast cancer stem cells (BCSCs) are a small proportion of cells that may be responsible\nfor improving the resistance of cancer cells to the treatment and metastasis of breast cancer (MBC).\nNanovehicles such as liposomes are extensively explored for diagnosis, treatment, and imaging of\ncancer. Targeted therapy with nanoparticles can be used to overcome the chemoresistance problem of\ncancer stem cells. Liposomes are lipid bilayer nanocarriers that have the ability to inhibit Pglycoprotein\nto overcome multidrug resistance that makes liposome ideal choice for using in BCSCs\ntherapy. The main objective of this review is to describe novel liposomal formulations that are used in\ntargeting BCSCs, which help in improving breast cancer treatment.\n","PeriodicalId":91228,"journal":{"name":"Clinical cancer drugs","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2212697X06666190318150757","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical cancer drugs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2212697X06666190318150757","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Breast cancer stem cells (BCSCs) are a small proportion of cells that may be responsible
for improving the resistance of cancer cells to the treatment and metastasis of breast cancer (MBC).
Nanovehicles such as liposomes are extensively explored for diagnosis, treatment, and imaging of
cancer. Targeted therapy with nanoparticles can be used to overcome the chemoresistance problem of
cancer stem cells. Liposomes are lipid bilayer nanocarriers that have the ability to inhibit Pglycoprotein
to overcome multidrug resistance that makes liposome ideal choice for using in BCSCs
therapy. The main objective of this review is to describe novel liposomal formulations that are used in
targeting BCSCs, which help in improving breast cancer treatment.
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