EBV capsid antigen-immunoglobulin M antibody titer and serum EBV DNA load are associated with severity of patients with infectious mononucleosis: a retrospective analysis of clinical features of 250 cases

中华传染病杂志 Pub Date : 2018-10-15 DOI:10.3760/CMA.J.ISSN.1000-6680.2018.10.008

Niuniu Li, Jinghang Xu, Yiyi Shi, N. Huo, Guiqiang Wang, Xiaoyuan Xu

{"title":"EBV capsid antigen-immunoglobulin M antibody titer and serum EBV DNA load are associated with severity of patients with infectious mononucleosis: a retrospective analysis of clinical features of 250 cases","authors":"Niuniu Li, Jinghang Xu, Yiyi Shi, N. Huo, Guiqiang Wang, Xiaoyuan Xu","doi":"10.3760/CMA.J.ISSN.1000-6680.2018.10.008","DOIUrl":null,"url":null,"abstract":"Objective \nTo explore the possible associations between EBV capsid antigen-immunoglobulin M antibody (EBV-VCA-IgM), serum EBV DNA load and clinical severity, laboratory results in adolescent and adult patients with infectious mononucleosis (IM). \n \n \nMethods \nClinical data of 250 adolescent and adult IM patients were retrospectively analyzed. Patients were divided into two groups by EBV-VCA-IgM titer (>160 U/mL or≤160 U/ mL) and serum EBV DNA level (>3.38 lg copies/mL or <3.38 lg copies/mL), respectively. Clinical data were compared between the two groups, respectively. The t test was used for intergroup comparison and the Mann-Whitney U test was used for non-normally distributed data. \n \n \nResults \nCompared with those with lower VCA-IgM antibody titer (≤160 U/ mL), sore throat (83.0% [122/147] vs 67.2%[43/64], χ2=6.534, P=0.011), pharynx secretion (59.9% [88/147] vs 40.6% [26/64], χ2=6.645, P=0.010), and swollen tonsils (78.9% [116/147] vs 59.4% [38/64], χ2=8.631, P=0.003) were more common in those with higher VCA-IgM antibody titer (>160 U/mL). ALT level was higher as well in those with higher VCA-IgM antibody titer (290.5[168.0, 460.5] U/L vs 221.0[113.0, 440.5] U/L, Z=-2.251, P=0.024). The peak body temperature ([39.2±0.7] °C vs [38.7±0.7] °C, t=-3.150, P=0.002), maximum WBC counts (16.2 [12.2, 20.4]×109/L vs 13.4[11.1, 17.3] ×109/L, Z=-2.098, P=0.036), maximum percentage of lymphocyte ([72.0±7.8]% vs [68.2±7.0]%, t=-2.238, P=0.028), and lymphocyte EBV DNA load ([5.5±0.9] lg copies/mL vs [4.8±1.0] lg copies/mL, t=-2.602, P=0.012) in those with higher serum EBV DNA load >3.38 lg copies/mL were higher than those with serum EBV DNA load <3.38 lg copies/mL. Regression analysis showed that serum EBV DNA load was associated with the peak body temperature (regression coefficient 0.368, P=0.003) and lymphocyte EBV DNA load (regression coefficient 0.389, P=0.002). \n \n \nConclusions \nIn adolescents and adults, EBV-VCA-IgM antibody titer and serum EBV DNA load are associated with severity of patients with infectious mononucleosis. \n \n \nKey words: \nInfectious mononucleosis; Virology; Adult; Adolescent; Severity","PeriodicalId":10127,"journal":{"name":"中华传染病杂志","volume":"36 1","pages":"616-621"},"PeriodicalIF":0.0000,"publicationDate":"2018-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华传染病杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1000-6680.2018.10.008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective To explore the possible associations between EBV capsid antigen-immunoglobulin M antibody (EBV-VCA-IgM), serum EBV DNA load and clinical severity, laboratory results in adolescent and adult patients with infectious mononucleosis (IM). Methods Clinical data of 250 adolescent and adult IM patients were retrospectively analyzed. Patients were divided into two groups by EBV-VCA-IgM titer (>160 U/mL or≤160 U/ mL) and serum EBV DNA level (>3.38 lg copies/mL or <3.38 lg copies/mL), respectively. Clinical data were compared between the two groups, respectively. The t test was used for intergroup comparison and the Mann-Whitney U test was used for non-normally distributed data. Results Compared with those with lower VCA-IgM antibody titer (≤160 U/ mL), sore throat (83.0% [122/147] vs 67.2%[43/64], χ2=6.534, P=0.011), pharynx secretion (59.9% [88/147] vs 40.6% [26/64], χ2=6.645, P=0.010), and swollen tonsils (78.9% [116/147] vs 59.4% [38/64], χ2=8.631, P=0.003) were more common in those with higher VCA-IgM antibody titer (>160 U/mL). ALT level was higher as well in those with higher VCA-IgM antibody titer (290.5[168.0, 460.5] U/L vs 221.0[113.0, 440.5] U/L, Z=-2.251, P=0.024). The peak body temperature ([39.2±0.7] °C vs [38.7±0.7] °C, t=-3.150, P=0.002), maximum WBC counts (16.2 [12.2, 20.4]×109/L vs 13.4[11.1, 17.3] ×109/L, Z=-2.098, P=0.036), maximum percentage of lymphocyte ([72.0±7.8]% vs [68.2±7.0]%, t=-2.238, P=0.028), and lymphocyte EBV DNA load ([5.5±0.9] lg copies/mL vs [4.8±1.0] lg copies/mL, t=-2.602, P=0.012) in those with higher serum EBV DNA load >3.38 lg copies/mL were higher than those with serum EBV DNA load <3.38 lg copies/mL. Regression analysis showed that serum EBV DNA load was associated with the peak body temperature (regression coefficient 0.368, P=0.003) and lymphocyte EBV DNA load (regression coefficient 0.389, P=0.002). Conclusions In adolescents and adults, EBV-VCA-IgM antibody titer and serum EBV DNA load are associated with severity of patients with infectious mononucleosis. Key words: Infectious mononucleosis; Virology; Adult; Adolescent; Severity

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

EBV衣壳抗原-免疫球蛋白M抗体滴度和血清EBV DNA载量与传染性单核细胞增多症患者的严重程度相关:对250例临床特征的回顾性分析

目的探讨青少年和成人传染性单核细胞增多症(IM)患者EBV衣壳抗原-免疫球蛋白M抗体(EBV- vca - igm)、血清EBV DNA载量与临床严重程度、实验室结果的关系。方法回顾性分析250例青少年及成人IM患者的临床资料。根据EBV- vca - igm滴度(>为160 U/mL或≤160 U/mL)和血清EBV DNA水平(>为3.38 lg拷贝/mL或160 U/mL)将患者分为两组。VCA-IgM抗体滴度高的患者ALT水平也较高(290.5[168.0,460.5]U/L vs 221.0[113.0, 440.5] U/L, Z=-2.251, P=0.024)。血清EBV DNA负荷较高组的峰值体温([39.2±0.7]°C vs[38.7±0.7]°C, t=-3.150, P=0.002)、最大白细胞计数(16.2 [12.2,20.4]×109/L vs 13.4[11.1, 17.3] ×109/L, Z=-2.098, P=0.036)、最大淋巴细胞百分比([72.0±7.8]% vs[68.2±7.0]%，t=-2.238, P=0.028)、淋巴细胞EBV DNA负荷([5.5±0.9]lg拷贝/mL vs[4.8±1.0]lg拷贝/mL, t=-2.602, P=0.012)均高于血清EBV DNA负荷<3.38 lg拷贝/mL组。回归分析显示，血清EBV DNA载量与体温峰值(回归系数0.368,P=0.003)和淋巴细胞EBV DNA载量(回归系数0.389,P=0.002)相关。结论在青少年和成人中，EBV- vca - igm抗体滴度和血清EBV DNA载量与传染性单核细胞增多症患者的严重程度相关。关键词:传染性单核细胞增多症;病毒学;成年人;青少年;严重程度

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

中华传染病杂志

自引率

0.00%

发文量

5280

期刊介绍： The Chinese Journal of Infectious Diseases was founded in February 1983. It is an academic journal on infectious diseases supervised by the China Association for Science and Technology, sponsored by the Chinese Medical Association, and hosted by the Shanghai Medical Association. The journal targets infectious disease physicians as its main readers, taking into account physicians of other interdisciplinary disciplines, and timely reports on leading scientific research results and clinical diagnosis and treatment experience in the field of infectious diseases, as well as basic theoretical research that has a guiding role in the clinical practice of infectious diseases and is closely integrated with the actual clinical practice of infectious diseases. Columns include reviews (including editor-in-chief reviews), expert lectures, consensus and guidelines (including interpretations), monographs, short monographs, academic debates, epidemic news, international dynamics, case reports, reviews, lectures, meeting minutes, etc.