Natural polymer-based adhesive hydrogel for biomedical applications

IF 1.6 Q4 ENGINEERING, BIOMEDICAL Biosurface and Biotribology Pub Date : 2022-06-07 DOI:10.1049/bsb2.12036
Siyu Long, Chaoming Xie, Xiong Lu
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引用次数: 3

Abstract

Hydrogel is a polymer network system that can form a hydrophilic three-dimensional network structure through different cross-linking methods. In recent years, hydrogels have received considerable attention due to their good biocompatibility and biodegradability by introducing different cross-linking mechanisms and functional components. Compared with synthetic hydrogels, natural polymer-based hydrogels have low biotoxicity, high cell affinity, and great potential for biomedical fields; however, their mechanical properties and tissue adhesion capabilities have been unable to meet clinical requirements. In recent years, many efforts have been made to solve these issues. In this review, the recent progress in the field of natural polymer-based adhesive hydrogels is highlighted. The authors first introduce the general design principles for the natural polymer-based adhesive hydrogels being used as excellent tissue adhesives and the challenges associated with their design. Next, their usages in biomedical applications are summarised, such as wound healing, haemostasis, nerve repair, bone tissue repair, cartilage tissue repair, electronic devices, and other tissue repairs. Finally, the potential challenges of natural polymer-based adhesive hydrogels are presented.

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用于生物医学应用的天然聚合物基粘合剂水凝胶
水凝胶是一种聚合物网络体系,可以通过不同的交联方式形成亲水性的三维网络结构。近年来,通过引入不同的交联机制和功能组分,水凝胶因其良好的生物相容性和生物降解性而备受关注。与人工合成的水凝胶相比,天然聚合物基水凝胶具有生物毒性低、细胞亲和力高的特点,在生物医学领域具有很大的应用潜力;然而,它们的力学性能和组织粘附能力还不能满足临床要求。近年来,人们为解决这些问题做出了许多努力。本文综述了近年来天然聚合物基胶粘剂水凝胶领域的研究进展。作者首先介绍了天然聚合物基胶粘剂水凝胶作为优良组织胶粘剂的一般设计原则及其设计中面临的挑战。其次,总结了它们在生物医学中的应用,如伤口愈合、止血、神经修复、骨组织修复、软骨组织修复、电子设备和其他组织修复。最后,提出了天然聚合物基胶粘剂水凝胶的潜在挑战。
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来源期刊
Biosurface and Biotribology
Biosurface and Biotribology Engineering-Mechanical Engineering
CiteScore
1.70
自引率
0.00%
发文量
27
审稿时长
11 weeks
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