Effect of Lawsonia inermis (Henna) on wound healing in Sprague-Dawley rats: A pilot study

Q1 Medicine Wound Medicine Pub Date : 2017-09-01 DOI:10.1016/j.wndm.2017.07.004

Abdulwahid M. Salih , Fahmi H. Kakamad , Rawezh Q. Salih , Dahat A. Hussein , Hunar A. Hassan , Tomas M. Mekail , Jeza M. Abdul Aziz , Han Aube

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引用次数: 5

Abstract

Leaves of Lawsonia inermis have long been used for several purposes in traditional herbal medicine. This report is to evaluate the effect of Lawsonia inermis on the wound healing in rats. Eight adult male rats were used. Animals have been anesthetized. A wound was created on the dorsal nape of the neck. Group 1 were left without treatment. Group 2 treated with 10% Iodine and vehicle. Group 3 and 4 were treated with a low dose and high dose of Henna respectively for 15 days. On the 1 ,5,10 and 15, the wound area of each animal was measured. Wound contraction was calculated. On the day 15, tissue samples were taken from the wound and examined by a histopathologist. At day 15, the average wound size decreased in group 1 and group 2 to 5.5 mm and 6.5 mm respectively and in group 3 and group 4 to 0 and 2.5 mm respectively. Histological results revealed that low dose and high dose produce better wound healing if compared with the control positive and control negative. The result of this pilot study has revealed that Henna extract leaves have remarkable effects on wound healing and warrents further studies.

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指甲花对Sprague-Dawley大鼠伤口愈合影响的初步研究

长时间以来，月桂草的叶子在传统草药中有多种用途。本报告旨在评价刺槐对大鼠创面愈合的影响。使用8只成年雄性大鼠。动物被麻醉了。颈背处有一处伤口。第一组患者不进行治疗。第二组给予10%碘和机动车治疗。第3组和第4组分别给予低剂量和高剂量指甲花治疗，疗程15 d。在第1、5、10、15天分别测量各组动物的伤口面积。计算伤口收缩。在第15天，从伤口中取出组织样本并由组织病理学家检查。第15天，1组和2组的平均创面大小分别减小至5.5 mm和6.5 mm, 3组和4组的平均创面大小分别减小至0和2.5 mm。组织学结果显示，与对照阳性和对照阴性相比，低剂量和高剂量组创面愈合较好。本初步研究结果表明，指甲花提取物叶对伤口愈合有显著作用，值得进一步研究。

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Wound Medicine Medicine-Surgery

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