Headache highlights 2019: Junior editors’ choice

Abstract

In the year 2019 in research on headache disorders, migraine remains the focus of attention as the antibodies against calcitonin gene-related peptide (CGRP) and its receptor have become available in several countries along with the publication of phase 3 clinical trials of the newer generation oral CGRP receptor antagonists. Aside from the overshadowing CGRP research, several other interesting studies have been published. Herewith, we provide an overview of the publications that, in our opinion, contribute greatly to the understanding and treatment of headache disorders. Of note, the selection for the list is subjective and does not include all research works in the year of 2019 worthy of mention. We hope that our selection serves as a short summary and a catalyst to increase the interests of headache researchers. In the current editorial, we will discuss preclinical and clinical studies, which provide a better understanding of the disease mechanisms or a potential to future treatment targets.