Synthesis and characterization of PCU@C-Ag/AgCl nanoparticles as an antimicrobial material for respiratory tract infection

IF 3.3 Q3 NANOSCIENCE & NANOTECHNOLOGY Nanofabrication Pub Date : 2021-01-01 DOI:10.1515/nanofab-2020-0106
S. Palanisamy, Kalaivani Subramanian, Lerince Godrina Bennet, Janani Ambrose, Aganiya Gopalakrishnan, Sudhagar Babu, R. Rajamani, N. Jha, Soumya Pandit, S. Singh, K. Dua, P. K. Gupta
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引用次数: 1

Abstract

Abstract The pregnant cow urine (PCU) is an active source of antimicrobial agents that is used for fabricating chitosan coated Ag/AgCl nanoparticles (NPs) in the present study. These PCU@C-Ag/AgCl NPs were physicochemically characterized and evaluated for antimicrobial activity against selected respiratory tract infection (RTI) pathogens. The absorption band around 420 nm in UV-Visible spectrum indicated the presence of Ag NPs. The spherical shape of NPs was observed using TEM. Also, the crystalline structure was confirmed using the XRD pattern. The PCU@C-Ag/AgCl NPs showed strong antimicrobial activity against all tested RTI pathogens. In addition, FESEM analysis showed morphological changes in RTI bacterial pathogens. Thereby, PCU@C-Ag/AgCl NPs may be used as an antimicrobial material to treat RTIs in near future at clinical level.
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呼吸道感染抗菌材料PCU@C-Ag/AgCl纳米颗粒的合成与表征
摘要孕牛尿(PCU)是本研究中用于制备壳聚糖包被的Ag/AgCl纳米颗粒(NP)的抗菌剂的活性来源。这些PCU@C-Ag/对氯化银纳米粒子进行物理化学表征,并评估其对选定呼吸道感染(RTI)病原体的抗菌活性。紫外可见光谱中420nm附近的吸收带表明Ag NP的存在。使用TEM观察了纳米颗粒的球形。此外,使用XRD图案确认了结晶结构。这个PCU@C-Ag/AgCl纳米粒子对所有测试的RTI病原体都表现出强大的抗菌活性。此外,FESEM分析显示RTI细菌病原体的形态学变化。因此PCU@C-Ag/在不久的将来,氯化银纳米粒子可以作为一种抗微生物材料在临床水平上治疗RTI。
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来源期刊
Nanofabrication
Nanofabrication NANOSCIENCE & NANOTECHNOLOGY-
自引率
10.30%
发文量
13
审稿时长
16 weeks
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