Chemical components in cultivated Cordyceps sinensis and their effects on fibrosis

IF 4.7 4区 医学 Q1 CHEMISTRY, MEDICINAL Chinese Herbal Medicines Pub Date : 2024-01-01 DOI:10.1016/j.chmed.2022.11.008
Zhonghua Dong , Xiao Sun
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Abstract

Objective

Cultivated Cordyceps sinensis powder has been used as clinical drug and healthy food to nourish the lung and kidney, which solves the problem of serious shortage of wild C. sinensis. This study aims to explore the chemical components and compared their anti-fibrotic effects in cultivated C. sinensis.

Methods

Nucleosides, sterols and polysaccharides were separated and purified from cultivated C. sinensis, and analyzed by high performance liquid chromatography, gas chromatography-mass spectrometry and chemical chromogenic methods, respectively. In high glucose-induced rat mesangial cell models, fibronectin and type 1 collagen were used as evaluation indicators.

Results

There were 10 kinds of nucleosides and one sterol in cultivated C. sinensis. The contents of nucleosides, sterols and polysaccharides in the cultivated C. sinensis were close to 2%, 0.55% and 4.4%, respectively. Furthermore, nucleoside, sterol and polysaccharide components exhibited varying degrees of anti-fibrotic activity. The nucleoside components and sterol components inhibited the expression of extracellular matrix more effectively in the three main components.

Conclusion

Cultivated C. sinensis remains the similar compounds with the wild C. sinensis, and nucleosides and sterols may be the main active substances that contribute to its anti-fibrotic effects. The project of this study may provide valuable information on further optimization of more effective remedies with few side effects based on cultivated C. sinensis.

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人工冬虫夏草化学成分及其对纤维化的影响
目的人工栽培的冬虫夏草已作为临床药物和滋补肺肾的保健食品,解决了野生冬虫夏草严重缺乏的问题。方法从栽培冬虫夏草中分离纯化出核苷类、甾醇类和多糖类物质,分别用高效液相色谱法、气相色谱-质谱法和化学发色法进行分析。在高糖诱导的大鼠间质细胞模型中,以纤维粘连蛋白和 1 型胶原蛋白作为评价指标。其中核苷、甾醇和多糖的含量分别接近 2%、0.55% 和 4.4%。此外,核苷、甾醇和多糖成分均表现出不同程度的抗纤维化活性。结论中药材栽培种仍具有与野生中药材相似的化合物,核苷和甾醇可能是其抗纤维化作用的主要活性物质。本研究项目可为进一步优化基于栽培冬凌草的更有效且副作用小的疗法提供有价值的信息。
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来源期刊
Chinese Herbal Medicines
Chinese Herbal Medicines CHEMISTRY, MEDICINAL-
CiteScore
4.40
自引率
5.30%
发文量
629
审稿时长
10 weeks
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