Preterm Labor, a Syndrome Attributed to the Combination of External and Internal Factors

Yuanyuan Liu, Lu Gao
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引用次数: 2

Abstract

Abstract Preterm labor (before 37 weeks’ gestation) is the leading cause of neonatal mortality and morbidity, which can be divided into iatrogenic preterm labor, infectious preterm labor, and spontaneous preterm labor (sPTL). Up to now, there continue to be great difficulties in prediction and prevention of sPTL, owing to multiple risk factors, pathogenesis, and pathologic processes contributing to the event, which have not been fully clarified. Pregnancy maintenance and parturition is a complicated process with continuous maternal-fetal dialogue, in which both maternal and fetal factors participate and affect the outcome of pregnancy, including sPTL. Besides, external factors can also participate in sPTL, individually or through the interaction with internal factors. In this article, we summarize recent studies regarding sPTL from our and other groups, and discuss the risk factors and pathogenesis of preterm birth from both external and internal (maternal and fetal) aspects, so as to provide theoretical evidences for the diagnosis, prevention, and treatment of sPTL in the future.
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早产,一种内外因素共同作用的综合征
早产(妊娠37周前)是新生儿死亡和发病的主要原因,可分为医源性早产、感染性早产和自发性早产(sPTL)。迄今为止,由于导致sPTL的危险因素、发病机制和病理过程多种多样,尚未完全清楚,因此在预测和预防sPTL方面仍然存在很大困难。妊娠维持和分娩是一个母胎持续对话的复杂过程,母胎因素共同参与并影响包括sPTL在内的妊娠结局。此外,外部因素也可以单独或通过与内部因素的相互作用参与sPTL。本文将对近年来本组及其他组关于sPTL的研究进行综述,并从外部和内部(母体和胎儿)两方面探讨早产的危险因素及发病机制,以期为今后sPTL的诊断、预防和治疗提供理论依据。
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