Prevalence and the Association of Body Mass Index and Other Risk Factors with Prediabetes and Type 2 Diabetes Among 50,867 Adults in China and Sweden: A Cross-Sectional Study.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Diabetes Therapy Pub Date : 2019-12-01 Epub Date: 2019-09-11 DOI:10.1007/s13300-019-00690-3

Yue Zhang, Ailiana Santosa, Na Wang, Weibing Wang, Nawi Ng, Qi Zhao, Yonggen Jiang, Lars Weinehall, Genming Zhao

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Abstract

Introduction: Understanding socioeconomic differences for prediabetes and type 2 diabetes (T2DM) can offer guidance for the most effective development of both prevention and intervention programmes in different settings. This study aims to determine the prevalence and risk factors for prediabetes and T2DM and to explore the effect of high body mass index (BMI) on the probability of T2DM being present among adults in China and Sweden.

Methods: This study enrolled 25,356 adults (35-64 years old) from the Shanghai Survey in China and 25,511 adults (aged 40, 50, 60) from the Västerbotten Intervention Programme in Sweden. Data on haemoglobin A1c, capillary fasting plasma glucose, 2-h plasma glucose and self-reported diagnoses of T2DM were used in the analysis. Multinomial logistic regression was used to examine the determinants of prediabetes and T2DM. The average predicted probabilities of T2DM developing or presenting were determined for the different ages and levels of BMI in each population.

Results: Chinese participants had a higher adjusted prevalence of T2DM (men 12.8% vs. 4.6%; women 10.6% vs. 3.1%) and prediabetes (men 12.4% vs. 12.2%; women 14.4% vs. 12.2%) than Swedish participants. Age, overweightedness/obesity, hypertension and a family history of diabetes were significant risk factors for prediabetes and T2DM. In both populations, the predicted probability of T2DM increased as the BMI increased in all age groups. At the same BMI level, Chinese participants were more likely to have T2DM compared to their Swedish counterparts. The average predicted probability of T2DM was less than 20% in nearly all age groups among Swedish women.

Conclusions: Chinese adults had the higher prevalence of prediabetes and T2DM and a higher probability of T2DM at the same BMI level compared with Swedish adults. These results indicate the importance of addressing the ongoing obesity epidemic as a matter of urgency in order to curb what has become an apparent diabetes epidemic in both countries.

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中国和瑞典50,867名成年人前驱糖尿病和2型糖尿病患病率及体重指数和其他危险因素的相关性:一项横断面研究

导言：了解糖尿病前期和二型糖尿病（T2DM）的社会经济差异，可为在不同环境下最有效地制定预防和干预计划提供指导。本研究旨在确定中国和瑞典成年人中糖尿病前期和 T2DM 的患病率和风险因素，并探讨高体重指数（BMI）对 T2DM 发生概率的影响：这项研究从中国上海调查和瑞典韦斯特博滕干预项目中分别招募了 25356 名成年人（35-64 岁）和 25511 名成年人（40、50、60 岁）。分析中使用了血红蛋白 A1c、毛细血管空腹血浆葡萄糖、2 小时血浆葡萄糖和自我报告的 T2DM 诊断数据。多项式逻辑回归用于研究糖尿病前期和 T2DM 的决定因素。根据每个人群的不同年龄和体重指数水平，确定了发生或出现 T2DM 的平均预测概率：结果：与瑞典人相比，中国人的调整后 T2DM 患病率（男性 12.8% 对 4.6%；女性 10.6% 对 3.1%）和糖尿病前期患病率（男性 12.4% 对 12.2%；女性 14.4% 对 12.2%）更高。年龄、超重/肥胖、高血压和糖尿病家族史是糖尿病前期和 T2DM 的重要风险因素。在这两种人群中，随着所有年龄组的体重指数（BMI）的增加，T2DM的预测概率也随之增加。在相同的体重指数水平下，与瑞典人相比，中国人更容易患上T2DM。几乎在所有年龄组中，瑞典女性患 T2DM 的平均预测概率都低于 20%：结论：与瑞典成年人相比，中国成年人的糖尿病前期和 T2DM 患病率较高，在相同的 BMI 水平下，中国成年人患 T2DM 的概率较高。这些结果表明，当务之急是解决目前肥胖症流行的问题，以遏制两国明显的糖尿病流行。

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来源期刊

Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism

自引率

7.90%

发文量

130

期刊介绍： Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.