{"title":"Genome-wide analysis of mouse cortical neurons lacking miR-27b","authors":"M. Gu, V.Y. Poon","doi":"10.1016/j.gdata.2015.11.021","DOIUrl":null,"url":null,"abstract":"<div><p>MicroRNAs (miRNAs), short non-coding RNAs that repress gene expression <span>[1]</span>, have recently emerged as important regulators of synaptic transmission and plasticity in the central nervous system <span>[2]</span>. This suggests an important role of this gene silencing mechanism in brain function both in health and disease states <span>[3]</span>. We previously reported a novel function of disease-associated miR-27b in promoting presynaptic assembly <span>[4]</span>. To further understand the role of this miRNA in the brain, we knocked down miR-27b in mouse cortical neurons and studied the impact of this perturbation on the transcriptome (GSE73275).</p></div>","PeriodicalId":56340,"journal":{"name":"Genomics Data","volume":"14 ","pages":"Pages 141-143"},"PeriodicalIF":0.0000,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.gdata.2015.11.021","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genomics Data","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221359601530091X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2015/12/3 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
MicroRNAs (miRNAs), short non-coding RNAs that repress gene expression [1], have recently emerged as important regulators of synaptic transmission and plasticity in the central nervous system [2]. This suggests an important role of this gene silencing mechanism in brain function both in health and disease states [3]. We previously reported a novel function of disease-associated miR-27b in promoting presynaptic assembly [4]. To further understand the role of this miRNA in the brain, we knocked down miR-27b in mouse cortical neurons and studied the impact of this perturbation on the transcriptome (GSE73275).
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