Caracterización e implantación de un relleno de ácido poliáctico para la regeneración ósea

Abstract

This article presents the characterization of a polylactic acid (PLA) matrix obtained via experimental procedure and its evaluation like a matrix to promote bone regeneration. The characterization included the chemical identification by Infrared Spectroscopy (FTIR), the thermal analysis by DSC and TGA, molecular weight measurement by viscosimetry and In-vitro hydrolytic degradation of the polymer was also studied to simulate the PLA application in the human body. At the final stage of evaluation the implantation of the material as a fill in the tibia of 30 rabbits was carried out to calculate the absorption percentage or bone growth. In the study, properties of lactic acid polymers like biocompatibility and biodegradability were used to produce a matrix to promote bone regeneration.