Protected or not? Hepatitis B vaccination status among healthcare workers and the level of protection post-vaccination

Q2 Medicine Medical Journal Armed Forces India Pub Date : 2024-12-01 DOI:10.1016/j.mjafi.2023.01.013

Manish Manrai , P. Harikrishnan , Rajesh Sahu , S.P.S. Shergill

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Abstract

Background

Hepatitis B virus infection is one of the major concerns in global health care. With a far-reaching health, social, economic impact, preventive strategies form the cornerstone of its management. Knowledge about vaccination status and protection rendered thereof would aid in more wholesome management among highrisk population groups like healthcare workers. The aim of this study was to evaluate the Hepatitis B vaccination status among Healthcare workers (HCW) and the level of protection post-vaccination.

Methods

During the study period a total of 420 HCWs were included in the study. The details of vaccination status was ascertained by an online questionnaire. Serum samples were evaluated for HBsAg status and Anti HBs titres to assess the level of protection against HBV infection. Those who were HBsAg negative, anti-HBc total was assessed.

Results

Our study revealed a high vaccination status among HCWs, n-384 (93.2%). However, the percentage of HCWs who were completely vaccinated was low (56.3%). Most of the study population, n-395 (95.6%) had protective titres of anti-HBs which showed a declining trend with increasing duration since the last dose of the vaccine.

Conclusion

Hepatitis B infection continues to be an important health hazard with significant morbidity and mortality. Healthcare workers are at higher risk of contracting the infection. Merely considering the vaccination status without knowing the protective anti-HBs titres is to be discouraged as it has been observed that the protective antibody titres show a declining trend with time as even completely vaccinated individuals had non-protective levels of antibody titres.

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是否受保护？医护人员乙肝疫苗接种情况及接种后防护水平

乙型肝炎病毒感染是全球卫生保健的主要问题之一。预防战略具有深远的健康、社会和经济影响，是其管理的基石。了解疫苗接种状况及其保护措施将有助于对卫生保健工作者等高危人群进行更健康的管理。本研究的目的是评估卫生保健工作者（HCW）的乙肝疫苗接种状况和疫苗接种后的保护水平。方法研究期间共纳入420名健康护理人员。通过在线问卷调查确定疫苗接种状况的细节。评估血清样本的HBsAg状态和抗HBs滴度，以评估对HBV感染的保护水平。检测HBsAg阴性者的抗- hbc总量。结果卫生保健工作者的疫苗接种率较高，n-384（93.2%）。然而，卫生保健工作者完全接种疫苗的比例很低（56.3%）。大多数研究人群n-395（95.6%）具有抗- hbs保护滴度，自最后一次接种疫苗以来，随着接种时间的增加，抗- hbs保护滴度呈下降趋势。结论乙型肝炎感染仍是一种重要的健康危害，发病率和死亡率均较高。卫生保健工作者感染这种病毒的风险较高。不鼓励仅仅考虑疫苗接种状态而不知道保护性抗hbs滴度，因为已经观察到保护性抗体滴度随着时间的推移呈下降趋势，即使完全接种疫苗的个体也有非保护性抗体滴度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Journal Armed Forces India Medicine-Medicine (all)

CiteScore

3.40

自引率

0.00%

发文量

206

期刊介绍： This journal was conceived in 1945 as the Journal of Indian Army Medical Corps. Col DR Thapar was the first Editor who published it on behalf of Lt. Gen Gordon Wilson, the then Director of Medical Services in India. Over the years the journal has achieved various milestones. Presently it is published in Vancouver style, printed on offset, and has a distribution exceeding 5000 per issue. It is published in January, April, July and October each year.