The different manifestations of ¹⁸F-FDG PET/CT and ⁶⁸Ga-FAPI-04 PET/CT in evaluation of the steroid therapy response for IgG4-related disease: A case report.

Frontiers in nuclear medicine (Lausanne, Switzerland) Pub Date : 2023-01-04 eCollection Date: 2022-01-01 DOI:10.3389/fnume.2022.1038797

Guorong Jia, Dejian Bian, Chao Cheng, Meitang Wang, Changjing Zuo

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Abstract

IgG4-related disease is a fibrous-inflammatory process belonging to immunomodulation disorders. We report a case of a 57-year-old man with the IgG4-related disease (RD). ⁶⁸Ga-FAPI-04 PET/CT showed more significant uptake in most lesions than in ¹⁸F-FDG PET/CT except for the cervical and mediastinal lymph nodes. Besides, uptake in the submandibular glands were only detected in ⁶⁸Ga-FAPI-04 PET/CT. The biopsy result of the cervical lymph nodes confirmed the diagnosis of IgG4-related disease. After treatment, only slight FDG-avid cervical lymph nodes were observed in the ¹⁸F-FDG PET/CT, while the raised uptake of ⁶⁸Ga-FAPI-04 could be observed in the pancreas and submandibular glands. ⁶⁸Ga-FAPI-04 PET-CT might have promising applications in evaluating IgG4-RD, whether in initial or follow-up imaging during steroid therapy.

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18F-FDG PET/CT和68Ga-FAPI-04 PET/CT在评估IgG4相关疾病类固醇治疗反应中的不同表现：一例报告

IgG4相关疾病是一种纤维炎症过程，属于免疫调节障碍。我们报告一例57岁男性IgG4相关疾病（RD）。68Ga-FAPI-04 PET/CT在除颈部和纵隔淋巴结外的大多数病变中显示出比18F-FDG PET/CT更显著的摄取。此外，在68Ga-FAPI-04 PET/CT中仅检测到下颌下腺的摄取。颈淋巴结活检结果证实了IgG4相关疾病的诊断。治疗后，在18F-FDG PET/CT中只观察到轻微的FDG狂热的颈部淋巴结，而在胰腺和下颌下腺中可以观察到68Ga-FAPI-04的摄取增加。68Ga-FAPI-04 PET-CT在评估IgG4 RD方面可能具有很好的应用前景，无论是在类固醇治疗期间的初始成像还是后续成像中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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