Neural plasticity of the uterus: New targets for endometrial cancer?

IF 2.7 Q2 OBSTETRICS & GYNECOLOGY Womens Health Pub Date : 2022-01-01 DOI:10.1177/17455057221095537
P. Español, Rocio Luna, C. Soler, Pablo Caruana, Amanda Altés-Arranz, Francisco Rodríguez, O. Porta, O. Sánchez, E. Llurba, R. Rovira, M. V. Céspedes
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引用次数: 5

Abstract

Endometrial carcinoma is the most common gynecological malignancy in Western countries and is expected to increase in the following years because of the high index of obesity in the population. Recently, neural signaling has been recognized as part of the tumor microenvironment, playing an active role in tumor progression and invasion of different solid tumor types. The uterus stands out for the physiological plasticity of its peripheral nerves due to cyclic remodeling brought on by estrogen and progesterone hormones throughout the reproductive cycle. Therefore, a precise understanding of nerve-cancer crosstalk and the contribution of the organ-intrinsic neuroplasticity, mediated by estrogen and progesterone, of the uterine is urgently needed. The development of new and innovative medicines for patients with endometrial cancer would increase their quality of life and health. This review compiles information on the architecture and function of autonomous uterine neural innervations and the influence of hormone-dependent nerves in normal uterus and tumor progression. It also explores new therapeutic possibilities for endometrial cancer using these endocrine and neural advantages.
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子宫神经可塑性:子宫内膜癌症的新靶点?
子宫内膜癌是西方国家最常见的妇科恶性肿瘤,由于人口肥胖指数高,预计在未来几年将增加。近年来,神经信号被认为是肿瘤微环境的一部分,在不同类型实体瘤的肿瘤进展和侵袭中发挥着积极的作用。子宫因其周围神经的生理可塑性而突出,这是由于在整个生殖周期中雌激素和孕激素引起的循环重塑。因此,迫切需要准确理解神经-肿瘤串扰以及子宫雌激素和孕激素介导的器官内在神经可塑性的作用。为子宫内膜癌患者开发新的和创新的药物将提高他们的生活质量和健康。本文综述了自主子宫神经支配的结构和功能,以及激素依赖性神经在正常子宫和肿瘤进展中的影响。它还探索了利用这些内分泌和神经优势治疗子宫内膜癌的新可能性。
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来源期刊
Womens Health
Womens Health OBSTETRICS & GYNECOLOGY-
CiteScore
2.80
自引率
4.20%
发文量
0
审稿时长
15 weeks
期刊介绍: For many diseases, women’s physiology and life-cycle hormonal changes demand important consideration when determining healthcare management options. Age- and gender-related factors can directly affect treatment outcomes, and differences between the clinical management of, say, an adolescent female and that in a pre- or postmenopausal patient may be either subtle or profound. At the same time, there are certain conditions that are far more prevalent in women than men, and these may require special attention. Furthermore, in an increasingly aged population in which women demonstrate a greater life-expectancy.
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