The Effect of a Common Daily Schedule on Human Circadian Rhythms During the Polar Day in Svalbard: A Field Study

Q2 Biochemistry, Genetics and Molecular Biology Journal of Circadian Rhythms Pub Date : 2019-10-09 DOI:10.5334/jcr.186
Kamila Weissová, Jitka Škrabalová, K. Skálová, Z. Bendová, J. Kopřivová
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引用次数: 11

Abstract

All Arctic visitors have to deal with extreme conditions, including a constant high light intensity during the summer season or constant darkness during winter. The light/dark cycle serves as the most potent synchronizing signal for the biological clock, and any Arctic visitor attending those regions during winter or summer would struggle with the absence of those entraining signals. However, the inner clock can be synchronized by other zeitgebers such as physical activity, food intake, or social interactions. Here, we investigated the effect of the polar day on the circadian clock of 10 researchers attending the polar base station in the Svalbard region during the summer season. The data collected in Svalbard was compared with data obtained just before leaving for the expedition (in the Czech Republic 49.8175°N, 15.4730°E). To determine the circadian functions, we monitored activity/rest rhythm with wrist actigraphy followed by sleep diaries, melatonin rhythm in saliva, and clock gene expression (Per1, Bmal1, and Nr1D1) in buccal mucosa samples. Our data shows that the two-week stay in Svalbard delayed melatonin onset but did not affect its rhythmic secretion, and delayed the activity/rest rhythm. Furthermore, the clock gene expression displayed a higher amplitude in Svalbard compared to the amplitude detected in the Czech Republic. We hypothesize that the common daily schedule at the Svalbard expedition strengthens circadian rhythmicity even in conditions of compromised light/dark cycles. To our knowledge, this is the first study to demonstrate peripheral clock gene expression during a polar expedition.
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在斯瓦尔巴群岛极地日,共同的日常日程安排对人类昼夜节律的影响:一项实地研究
所有的北极游客都必须面对极端的条件,包括夏季持续的强光照射和冬季持续的黑暗。光/暗周期是生物钟最有效的同步信号,任何在冬季或夏季前往这些地区的北极游客都将在缺乏这些信号的情况下挣扎。然而,内部时钟可以被其他的授时因子同步,比如身体活动、食物摄入或社会互动。在这里,我们调查了极日对夏季在斯瓦尔巴群岛地区极地基站工作的10名研究人员的生物钟的影响。在斯瓦尔巴群岛收集的数据与出发前获得的数据进行了比较(在捷克共和国49.8175°N, 15.4730°E)。为了确定昼夜节律功能,我们使用腕关节活动记录仪监测活动/休息节律,随后使用睡眠日记、唾液褪黑激素节律和颊粘膜样本中的时钟基因表达(Per1、Bmal1和Nr1D1)。我们的数据显示,在斯瓦尔巴群岛的两周停留延迟了褪黑激素的发作,但不影响其有节奏的分泌,并延迟了活动/休息节奏。此外,与在捷克共和国检测到的幅度相比,时钟基因在斯瓦尔巴群岛的表达幅度更高。我们假设,在斯瓦尔巴探险中,即使在光/暗周期受损的条件下,共同的日常时间表也会加强昼夜节律性。据我们所知,这是第一个在极地探险中展示外围时钟基因表达的研究。
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来源期刊
Journal of Circadian Rhythms
Journal of Circadian Rhythms Biochemistry, Genetics and Molecular Biology-Physiology
CiteScore
7.10
自引率
0.00%
发文量
0
审稿时长
12 weeks
期刊介绍: Journal of Circadian Rhythms is an Open Access, peer-reviewed online journal that publishes research articles dealing with circadian and nycthemeral (daily) rhythms in living organisms, including processes associated with photoperiodism and daily torpor. Journal of Circadian Rhythms aims to include both basic and applied research at any level of biological organization (molecular, cellular, organic, organismal, and populational). Studies of daily rhythms in environmental factors that directly affect circadian rhythms are also pertinent to the journal"s mission.
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