Emulation of Brain Metabolic Activities Based on a Dynamically Controllable Optical Phantom.

IF 10.5 Q1 ENGINEERING, BIOMEDICAL Cyborg and bionic systems (Washington, D.C.) Pub Date : 2023-09-13 eCollection Date: 2023-01-01 DOI:10.34133/cbsystems.0047

Yuxiang Lin, Cheng Chen, Zhouchen Ma, Nabil Sabor, Yanyan Wei, Tianhong Zhang, Mohamad Sawan, Guoxing Wang, Jian Zhao

{"title":"Emulation of Brain Metabolic Activities Based on a Dynamically Controllable Optical Phantom.","authors":"Yuxiang Lin, Cheng Chen, Zhouchen Ma, Nabil Sabor, Yanyan Wei, Tianhong Zhang, Mohamad Sawan, Guoxing Wang, Jian Zhao","doi":"10.34133/cbsystems.0047","DOIUrl":null,"url":null,"abstract":"<p><p>This paper presents a dynamic optical phantom for the simulation of metabolic activities in the brain, and a linear equivalent model is built for control voltage versus substance concentration. A solid-solid dynamic optical phantom is realized by using liquid crystal film as a voltage-controlled light intensity regulator on the surface of basic phantom, which uses epoxy resin as matrix material and nanometer carbon powder and titanium dioxide powder as absorption and scattering dopants, respectively. The dynamic phantom could mimic near-infrared spectrum (NIRS) signals with sampling rate up to 10 Hz, and the maximum simulation errors for oxy-hemoglobin and deoxy-hemoglobin concentrations varying in the range of 1 μmol/l are 7.0% and 17.9%, respectively. Compared with similar solid biomimetic phantoms, the adjustable mimic substance concentration range is extended by an order of magnitude, which meets the simulation requirements of most brain NIRS signals.</p>","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"1 1","pages":"0047"},"PeriodicalIF":10.5000,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651414/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cyborg and bionic systems (Washington, D.C.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34133/cbsystems.0047","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

This paper presents a dynamic optical phantom for the simulation of metabolic activities in the brain, and a linear equivalent model is built for control voltage versus substance concentration. A solid-solid dynamic optical phantom is realized by using liquid crystal film as a voltage-controlled light intensity regulator on the surface of basic phantom, which uses epoxy resin as matrix material and nanometer carbon powder and titanium dioxide powder as absorption and scattering dopants, respectively. The dynamic phantom could mimic near-infrared spectrum (NIRS) signals with sampling rate up to 10 Hz, and the maximum simulation errors for oxy-hemoglobin and deoxy-hemoglobin concentrations varying in the range of 1 μmol/l are 7.0% and 17.9%, respectively. Compared with similar solid biomimetic phantoms, the adjustable mimic substance concentration range is extended by an order of magnitude, which meets the simulation requirements of most brain NIRS signals.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

基于动态可控光体的脑代谢活动仿真

本文提出了一种用于模拟大脑代谢活动的动态光学幻影，并建立了控制电压与物质浓度的线性等效模型。以环氧树脂为基体材料，纳米碳粉和二氧化钛粉分别作为吸收和散射掺杂剂，利用液晶膜作为压控光强调节器，在基本型光体表面实现了固-固动态光体。动态模体可以模拟近红外光谱信号，采样率高达10 Hz，对氧血红蛋白和脱氧血红蛋白浓度在1 μmol/l范围内变化的最大模拟误差分别为7.0%和17.9%。与同类固体仿生模型相比，可调节的模拟物质浓度范围扩大了一个数量级，满足大多数脑近红外信号的模拟要求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊